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SUMMARY:ZOOM - ChemBio Seminar by Prof. Chang Liu (University of Californi
 a\, Irvine) – CH-635
DTSTART:20231107T161500
DTEND:20231107T171500
DTSTAMP:20260428T004634Z
UID:96619b01d2f7b94d1748992f3c4d505b32e63e6e45236d391bb7ce81
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Chang Liu\nTitle\nExperimental evolution of chosen genes 
 near their mutational speed limits\n\nAbstract\nMy laboratory engineers ge
 netic systems that go beyond what nature’s genetic systems can do. We ar
 e especially interested in creating genetic systems that dramatically acce
 lerate the speed of evolution and that record transient information as int
 erpretable mutations in DNA. We apply these systems to the generation of u
 seful biomolecules and therapeutics\; the study of molecular evolution\; a
 nd cell and developmental biology. I will discuss recent work on our ortho
 gonal DNA replication system for the continuous evolution of biomolecules 
 in vivo\, including enzymes and antibodies.\n\nBiography\nChang Liu is a
  Professor and Chancellor's Fellow of Biomedical Engineering\, Chemistry\,
  and Molecular Biology & Biochemistry and the Director of the Center for S
 ynthetic Biology at UC Irvine. Liu graduated from Harvard in 2005 with a
  bachelor’s degree in chemistry and carried out his PhD at the Scripps R
 esearch Institute. His PhD work\, done in the laboratory of Peter Schultz\
 , focused on expanding bacterial genetic codes for the co-translational in
 corporation of post-translational modifications and using expanded genetic
  codes in the evolution of novel protein function. From 2009-2012\, Liu 
 was a Miller Fellow at UC Berkeley where he worked with Adam Arkin on the 
 predictable design of complex regulatory systems using the special propert
 ies of RNA switches. In 2013\, Liu started his lab at UC Irvine. Liu’
 s research is in the fields of synthetic biology\, protein engineering\, 
 chemical biology\, and directed evolution. His group engineers specialized
  genetic systems that continuously and rapidly mutate user-selected genes
  in vivo. These systems allow researchers to evolve proteins at unprecede
 nted speed\, scale\, and depth in order to engineer new protein functions\
 , probe the rules of evolution\, and understand the fundamental sequence-f
 unction relationships governing proteins and other macromolecules. These s
 ystems also allow researchers to record transient information as heritable
  mutations in order to track animal and cancer development at high cellula
 r resolution.\n\nLab website\nwww.liulab.com\n 
LOCATION:https://epfl.zoom.us/j/64520311798
STATUS:CONFIRMED
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