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SUMMARY:Development of high-throughput lineage tracing tools and explorati
 on of the developmental mechanisms of stem/progenitor cells
DTSTART:20231030T113000
DTEND:20231030T121500
DTSTAMP:20260605T151633Z
UID:99a2da2ad4d5f96760dd5e7aafdfdcae7187f76becee1ad181cffb12
CATEGORIES:Conferences - Seminars
DESCRIPTION:Zhiwen You\nInstitute of Neuroscience\, Key Laboratory of Neur
 oscience\, CAS Center for Excellence in Brain Science and Intelligence Tec
 hnology\, Chinese Academy of Sciences\, Shanghai\, China\nAbstract: \n\nT
 he cell lineages across developmental stages remain to be elucidated. Here
 \, we developed single-cell split barcoding (SISBAR) that allows clonal tr
 acking of single-cell transcriptomes across stages in an in vitro model of
  human ventral midbrain-hindbrain differentiation. We uncovered many previ
 ously uncharacterized converging and diverging trajectories\, demonstratin
 g that a transcriptome-defined cell type can arise from distinct lineages\
 , and the multilineage fates of a progenitor cell-type is the collective r
 esults of distinct clonal fates of individual progenitors. Specifically\, 
 we uncovered a ventral midbrain progenitor cluster as the clonal origin of
  midbrain dopaminergic (mDA) neurons and identified a surface marker that 
 can improve graft outcomes.\n\nKey article:\nhttps://www.sciencedirect.com
 /science/article/pii/S1934590923000449 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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