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SUMMARY:Evolution of the outer mitochondrial membrane
DTSTART:20231205T121500
DTEND:20231205T131500
DTSTAMP:20260509T100747Z
UID:db36109bcd3d22489568c97560ab1f6d21433f2e344bdfb1e08045e8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Lena Pernas\, Dept. of Microbiology\, Immunology and Molecular
  Genetics\, UCLA\, Los Angeles\, USA / Metabolism of Infection Group\, Max
  Planck Institute for Biology of Ageing\, Cologne\, Germany / HHMI Freeman
  Hrabowski Scholar                            
                                      
                                      
  \nThe rewiring of mitochondrial metabolism serves as an innate immune-ty
 pe defense mechanism that restricts the growth of the human parasite Toxop
 lasma gondii. We recently reported a previously undescribed structure we t
 erm SPOT (structure positive for outer mitochondrial membrane (OMM) that e
 merges from the OMM during infection. We propose that Toxoplasma hijacks t
 he formation of SPOTs\, a cellular response to OMM import stress\, to prom
 ote its growth. Here\, I discuss the fate and function of these peculiar s
 tructures.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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