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SUMMARY:Metal-Catalyzed C–O Cleavage: Mechanistic Understanding and Appl
 ications in Chemical Synthesis
DTSTART:20231201T100000
DTEND:20231201T110000
DTSTAMP:20260916T063202Z
UID:8ff2484d27180bea74b1c28840f09e7f043227a9279fd61ed8bb1020
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Craig Day\, Massachusetts Instittute of Technology\n\nAbst
 ract\nThe mounting global concerns surrounding the sustainable manufacturi
 ng of pharmaceuticals\, materials\, and commodity chemicals have led chemi
 sts to pursue greener alternatives to existing processes.1 The development
  of reactions that directly functionalize naturally derived chemicals such
  as those originating from lignin and carbon dioxide offer a sustainable s
 olution to this societal need. Cleavage of the C–O linkages commonly enc
 ountered in these feedstocks\, however\, represents a significant barrier 
 due to the typically strong nature of these bonds. This seminar will prese
 nt mechanistic insights into this class of reactions and blueprints for th
 e development of future reactions.2-3\n\nReferences:\n1. Bullock\, R. M.\;
  Chen\, J. G.\; Gagliardi\, L.\; Chirik\, P. J.\; Farha\, O. K.\; Hendon\,
  C. H.\; Jones\, C. W.\; Keith\, J. A.\; Klosin\, J.\; Minteer\, S. D.\; M
 orris\, R. H.\; Radosevich\, A. T.\; Rauchfuss\, T. B.\; Strotman\, N. A.\
 ; Vojvodic\, A.\; Ward\, T. R.\; Yang\, J. Y.\; Surendranath\, Y. Using na
 ture's blueprint to expand catalysis with Earth-abundant metals. Science 2
 020\, 369 (6505)\, eabc3183.\n2. Day\, C. S.\; Somerville\, R. J.\; Martin
 \, R. Deciphering the dichotomy exerted by Zn(II) in the catalytic sp2 C
 –O bond functionalization of aryl esters at the molecular level. Nat. Ca
 tal. 2021\, 4 (2)\, 124-133.\n3. Day\, C. S.\; Ton\, S. J.\; Kaussler\, C.
 \; Vrønning Hoffmann\, D.\; Skrydstrup\, T. Low Pressure Carbonylation of
  Benzyl Carbonates and Carbamates for Applications in 13C Isotope Labeling
  and Catalytic CO2 Reduction. Angew. Chem. Int. Ed. 2023\, e202308238.\n\n
 \nFree Event - Limited seats\, please register to attend: https://bit.ly/D
 rCraigDay
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495 https://epfl.
 zoom.us/j/69462409594
STATUS:CONFIRMED
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