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SUMMARY:Time Flies\, How? Unlocking the Secrets of Aging
DTSTART:20231121T110000
DTEND:20231121T120000
DTSTAMP:20260405T163201Z
UID:2b486de35895f27cde6cfcf94a45c73da6bf193b2477cf3c029d87c7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Hongjie Li\, Baylor College of Medicine\, Houston\, TX (
 USA)\nBIOENGINEERING SEMINAR\n \nAbstract:\nAging phenotypes have been ob
 served and described for centuries and a number of different aging hypothe
 ses have been proposed. However\, several critical questions remain largel
 y unaddressed in complex organisms. For example\, do different cell types 
 age at the same rate? If not\, which cell types age the fastest across the
  whole body? Here I will present our recent work on the Aging Fly Cell Atl
 as\, a single-nucleus transcriptomic map of the whole aging Drosophila. We
  characterize 163 distinct cell types and perform an in-depth analysis of 
 changes in tissue cell composition\, gene expression\, and cell identities
 . We further develop aging clock models to predict the fly age. Based on t
 his platform\, we could now evaluate how pro-aging and pro-longevity mecha
 nisms impact different cell types across the entire body. I will also shar
 e one unpublished work called the Alzheimer’s Disease Fly Cell Atlas (AD
 -FCA): A whole-organism\, single-Cell sequencing resource on brain-body In
 teractions. This first whole-organism AD atlas enables us to uncover many 
 progressive changes that likely occur in non-neurological tissue in respon
 se to AD and offers fresh insights into the realm of brain-body communicat
 ion\, including many previously uncharted interactions.\n\nBio:\nHongjie L
 iu is an assistant professor at Baylor College of Medicine and CPRIT Schol
 ar in Huffington Center on Aging & Department of Molecular and Human Genet
 ics. Before starting his lab in 2021\, he was a postdoctoral researcher w
 ith Prof. Liqun Luo at Stanford University. He did his PhD with Dr. Henri 
 Jasper at University of Rochester and the Buck Institute for Research on A
 ging\, California. Hongjie pioneered the use of single-cell and single-nuc
 leus RNA sequencing in Drosophila and has been leading the Fly Cell Atlas 
 project. His lab recently established the Aging Fly Cell Atlas for studyin
 g whole organism aging at cellular resolution. His current research focuse
 s on applying single-cell sequencing technologies to understand whole-orga
 nism aging and inter-tissue communication during aging. His achievements h
 ave been recognized by several awards\, including the Stanford Neuroscienc
 e Institute Interdisciplinary Award\, NIH K99/R00 Award\, Cancer Preventio
 n and Research Institute of Texas (CPRIT) Award\, Impetus longevity resear
 ch Award\, Ted Nash Long Life Foundation Award\, and Welch Foundation Awar
 d.\n\n\n\n\nZoom link for attending remotely: https://epfl.zoom.us/j/61379
 058136?pwd=U1FmVGZhZEI1cVYzcnA5TWlRQUNZdz09\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/61379058136?pwd=U1FmVGZhZEI1cVYzcnA5TWlRQUNZdz09
STATUS:CONFIRMED
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