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SUMMARY:Alzheimer’s Drug Discovery Foundation – Drug Development Progr
 am
DTSTART;VALUE=DATE:20240205
DTSTAMP:20260916T014036Z
UID:724fea39191de9f917eed75b3d0605e96584a82f27187c40cfb4b708
CATEGORIES:Call for proposal
DESCRIPTION:The Drug Development call supports investigational new drug (I
 ND)-enabling studies (or the international equivalent) and early-phase cli
 nical trials that test promising pharmacological interventions and devices
  for Alzheimer’s disease (AD) and related dementias. Both disease-modify
 ing and symptomatic agents will be considered.\n\nThis funding opportunity
  prioritizes diverse drug mechanisms and modes of action related to the bi
 ology of aging and other emerging therapeutic areas for dementia. For this
  reason\, amyloid targeted approaches and cholinesterase inhibitor proposa
 ls will not be considered for this call.\n\nSpecifically\, the Drug Develo
 pment call supports the following stages of discovery:\n\n	Early-stage hum
 an clinical trials \n	Investigational new drug (IND)–enabling studies\n\
 n\nCurrent target areas of interest include:\n\n	Epigenetics\n	Inflammatio
 n\n	Mitochondria & metabolic function\n	Neuroprotection\n	Proteostasis\n	S
 ynaptic activity and neurotransmitters\n	Vascular function\n	Other mechani
 sms and modes of action related to the biology of aging (e.g. senescent ce
 lls)\n	Other novel targets or pathways that are supported by compelling ev
 idence demonstrating a rational biological connection to the disease proce
 ss\n	Anti-amyloid approaches (e.g.\, anti-amyloid aggregation\, beta-amylo
 id vaccines\, beta- or gamma-secretase inhibitors) and cholinesterase inhi
 bitor proposals will not be considered\n\n\nFunding:\nMax. $5\,000\,000 ba
 sed on stage and scope of research\n\nDuration: Multi-year\n\nEligibility:
 \nFunding is open to researchers and clinicians worldwide at academic medi
 cal centers and universities or nonprofits.\n\nHow to Apply:\nDeadlines fo
 r proposal submissions occur three times per year. Applications are review
 ed in a two-step process: Letters of Intent (LOIs) are the first step\, an
 d should be submitted on the ADDF Funding Portal. ADDF’s science team wi
 ll evaluate LOIs to determine whether the proposed project is consistent w
 ith the ADDF's mission and funding priorities. LOI decisions will be sent 
 within three weeks of submission. Step 2 is an invited full proposal\, whi
 ch should include a detailed project narrative\, budget and justification\
 , and biographical information.  When formulating the budget\, note that 
 the following costs are not covered: Indirect costs/Overhead\, Publication
  costs\, Equipment\, and Travel.\n\nWinter Deadlines:\n\n\n	05 February 20
 24 (LOI)\n	08 April 2024 (full proposal\, by invitation)\n\n\nSpring Deadl
 ines:\n\n\n	13 May 2024 (LOI)\n	22 July 2024 (full proposal\, by invitatio
 n)\n\n\nAutumn Deadlines:\n\n\n	30 September 2024 (LOI)\n	09 December 2024
  (full proposal\, by invitation)\n\n\nFurther information\n\n\n	More infor
 mation about the program is available here\n	Detailed application instruct
 ions are here\n	The application portal can be found here\n\nFor any other 
 questions\, please contact the Research Office
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STATUS:CONFIRMED
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