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SUMMARY:Genetically Programmed Synthesis of non-natural Polymers and Macro
 cyclic (Depsi-) peptides
DTSTART:20231206T103000
DTEND:20231206T113000
DTSTAMP:20260930T213414Z
UID:d60c4ff2ed8655857ebebbe4c6ee2c4a7af630bb07d62afc4165fdfd
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Martin Spinck\, MRC Laboratory of Molecular Biology\, Unit
 ed Kingdom\nAbstract\n\nRecent advancements in whole genome synthesis of a
 n artificial E. coli cell with a reprogrammed genetic code have liberated 
 three codons for reassignment. These "blank" codons can be reassigned to e
 ncode various non-canonical amino- and/or alpha-hydroxy acids. The reassig
 nment of multiple orthogonal tRNA/-synthetase pairs\, including hydroxy ac
 id selective variants\, allows for the rapid\, genetically programmed synt
 hesis of diverse non-canonical polymers and (depsi-) peptide macrocycles. 
 This provides a promising platform for the discovery of artificial polymer
 s and macrocycles\, demonstrating the potential for creating biochemically
  diverse molecules within a living cell.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495 https://epfl.
 zoom.us/j/67532881088
STATUS:CONFIRMED
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