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SUMMARY:Engineering Heme Enzymes to Navigate New-to-Nature Reaction Space
DTSTART:20231207T140000
DTEND:20231207T150000
DTSTAMP:20260928T175443Z
UID:9fe7f96835494501b327aaa1062b4b479add7fc6b17a7d043d82f45a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Runze Mao\, California Institute of Technology\, United St
 ates\nAbstract\n\nDNA-programmable chemical synthesis using enzymes holds 
 great potential to advance conventional synthetic processes\, especially i
 n sustainability\, efficiency\, and selectivity. Despite its promise\, enz
 yme catalysis is currently hampered by a limited catalytic repertoire. To 
 address this\, we have leveraged directed evolution to engineer heme enzym
 es that push the boundaries of nature’s synthetic capabilities. These re
 search endeavors have unlocked previously unknown chemical space of enzyme
  catalysis and overcome synthetic challenges where existing biological and
  synthetic methods falter. Moreover\, combined experiments and computation
 al studies\, including DFT calculations and MD simulations\, have deepened
  our understanding of these heme enzymes' novel functions.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495 https://epfl.
 zoom.us/j/68697123603
STATUS:CONFIRMED
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