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SUMMARY:Pushing the Boundaries of Catalysis for Chemical Synthesis: Pallad
 ium-Catalyzed Carbonylations and Photoenzymatic Catalysis
DTSTART:20231208T110000
DTEND:20231208T120000
DTSTAMP:20260916T081913Z
UID:83ebd102f668e2d1df39548ac2166c49ba05126a97c9419bac3184ea
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Yi Liu\, Princeton University\, United States\nAbstract\n\
 nIn this presentation\, I will explore two catalytic paradigms—transitio
 n-metal catalysis and enzymatic catalysis—enhanced by photochemistry. Wh
 ile transition-metal catalysis\, exemplified by palladium-catalyzed carbon
 ylations\, has revolutionized organic synthesis\, limitations persist. Our
  approach uses visible light to decouple classical electronic and steric i
 nfluences\, overcoming hindrances in both oxidative addition and reductive
  elimination steps. Moreover\, enzymes are unrivaled catalysts\, exhibitin
 g exceptional reactivity and selectivity. I will discuss expanding enzymat
 ic reactions through photochemistry. We introduce new mechanisms\, enablin
 g the asymmetric synthesis of α-chloroamides and redox-neutral cross-coup
 ling reactions. The latter opens a new avenue for Csp3-Csp3 cross-coupling
 s using Flavin-enzymes.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495 https://epfl.
 zoom.us/j/68881661624
STATUS:CONFIRMED
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