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SUMMARY:The Michael J. Fox Foundation - Therapeutics Pipeline Program
DTSTART;VALUE=DATE:20240111
DTSTAMP:20260528T031201Z
UID:839f708eca77f71d8388afba4112b97e8cd26d322842b9f98130ae2d
CATEGORIES:Call for proposal
DESCRIPTION:The Parkinson’s Disease Therapeutics Pipeline Program advanc
 es therapeutic development through pre-clinical and/or into clinical testi
 ng of approaches addressing unmet needs of people with PD with clear poten
 tial to prevent\, stop\, or delay disease progression or to reduce the bur
 den of daily symptoms. As the requirements for delivering new treatments i
 nto the market depend on specialized expertise and resources\, a unique go
 al of this program is to promote clearer paths to commercialization and ma
 rket access by the PD community. Therefore\, we are only accepting applica
 tions from industry groups or academic teams working in collaboration with
  a dedicated industry partner capable of further commercial development of
  a promising intervention.\n\nMJFF prioritizes pre-clinical and clinical p
 rograms that may slow\, stop\, or prevent disease progression\, efforts th
 at address moderate-to-advanced motor or non-motor symptoms of Parkinson
 ’s not well-managed by current treatments such as advanced gait disturba
 nces (e.g.\, balance issues linked to falls\, freezing) and cognitive chan
 ges.\n\nFor this program\, MJFF will not consider proposals focused on the
  following:\n\n	Applications seeking to identify new intervention targets 
 (e.g.\, large-scale screening or genomic/transcriptomic analyses).\n	Appli
 cations seeking to validate a target with only tool compounds or biologica
 l manipulations that have no viable path for further drug optimization and
  development.\n	Applications seeking to test reformulation of commercially
  available drugs via a new route of administration.\n	Application seeking 
 to assess efficacy of dietary supplements.\n\n\nFunding:\nFrom $250\,000 f
 or smaller\, targeted programs to upwards of $2M for larger\, multi-stage 
 preclinical and/or clinical programs\n\nDuration:\n1 to 2 years for pre-cl
 inical programs\n2 to 3 years for clinical programs\n\nEligibility:\nAppli
 cations may be submitted by researchers or clinicians in:\n\n	U.S. and non
 -U.S. public and private non-profit entities\, such as universities\, coll
 eges\, hospitals\, laboratories\, units of state and local governments\, a
 nd eligible agencies of the federal government in collaboration with biote
 chnology/pharmaceutical/medical device companies\, or other publicly or pr
 ivately held for-profit entities.\n	 \n	MJFF encourages the inclusion of 
 researchers who span career stages.\n	 \n	Early career investigators (wit
 hin 1-7 years of first independent appointment or equivalent) are encourag
 ed to apply and are permitted to serve as Principal Investigator (PI)\; Po
 st-doctoral fellows are permitted to serve as Co-Principal Investigator (C
 o-PI). Training and fellowship activities are not supported through this p
 rogram.\n\n\nHow to Apply:\nThe two-stage application process begins with 
 an LOI\, which can be submitted on a rolling basis on the MJFF Grant Porta
 l. Instructions for pre-proposal submission vary if submitting a pre-clini
 cal project or a clinical project. Selected applicants will be notified wi
 thin three weeks and will be invited to submit a full proposal by one of t
 he four deadlines (see below). Budgets should be formulated to include 15%
  OH.\n\nDeadlines (full proposals):\n\n\n	11 January 2024\n	14 March 2024\
 n	16 May 2024\n	27 June 2024\n\n\nFurther information\n\n\n	More informati
 on about the program is available here and the full RFA is available here\
 n	Application portal can be found here\n\nFor any other questions\, please
  contact the Research Office
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STATUS:CONFIRMED
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