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VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:BMI Seminar // Hiroki R. Ueda "Towards Human Systems Biology of Sl
 eep/Wake Cycles: Phosphorylation Hypothesis of Sleep"
DTSTART:20240115T150000
DTEND:20240115T160000
DTSTAMP:20261005T212559Z
UID:63e104f7dae5e33c5b6b3d6c7f84f6c7d05dbe40701b8c823dc902be
CATEGORIES:Conferences - Seminars
DESCRIPTION:Hiroki R. Ueda\, M.D.\, Ph.D\, Professor\, Graduate School of 
 Medicine\, University of Tokyo\nTeam Leader\, RIKEN BDR\nhttp://www.qbic.r
 iken.jp/syn-bio/\n \nThe field of human biology faces three major technol
 ogical challenges. Firstly\, the causation problem is difficult to address
  in humans compared to model animals. Secondly\, the complexity problem ar
 ises due to the lack of a comprehensive cell atlas for the human body\, de
 spite its cellular composition. Lastly\, the heterogeneity problem arises 
 from significant variations in both genetic and environmental factors amon
 g individuals. To tackle these challenges\, we have developed innovative a
 pproaches. These include 1) mammalian next-generation genetics\, such as T
 riple CRISPR for knockout (KO) mice and ES mice for knock-in (KI) mice\, w
 hich enables causation studies without traditional breeding methods\; 2) w
 hole-body/brain cell profiling techniques\, such as CUBIC\, to unravel the
  complexity of cellular composition\; and 3) accurate and user-friendly te
 chnologies for measuring sleep and awake states\, exemplified by ACCEL\, t
 o facilitate the monitoring of fundamental brain states in real-world sett
 ings and thus address heterogeneity in human.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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