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SUMMARY:BMI Seminar // Katharina Gapp: A novel tool to combat stress (-hor
 mone receptor) signatures
DTSTART:20240424T121500
DTEND:20240424T131500
DTSTAMP:20260501T180456Z
UID:005b070ae097e90a5f7f1d94dfa10185fa3fb4cfaddddd817e7972fb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Katharina Gapp\, ETHZ\nI will discuss the environmental impact
  on stress hormone signaling and potential consequences on brain gene expr
 ession in priming neuropsychiatric disease risk. In particular\, we will c
 onsider chronic and acute stress models in mice\, their hormonal\, gene\, 
 and behavior dysregulation and thus explore glucocorticoid signaling as a 
 target for treatment. To this end\, I will introduce our custom-developed 
 Proteolysis targeting chimera tool that depletes the glucocorticoid recept
 or\, one of the main stress hormone receptors\, with unprecedented specifi
 city at the protein level. I will demonstrate its applicability to difficu
 lt-to-target systems\, such as primary neuronal cells\, to elucidate impac
 ts on neuronal activity\, its translatability across species\, and its eff
 ectiveness in vivo.\nIn the second part of my talk\, we will turn toward t
 he long-lasting – generation-spanning - impact of stress on behavior and
  metabolism and delineate glucocorticoid signaling in the germline among o
 ther mechanisms as a potential mediator of intergenerational transmission.
  \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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