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SUMMARY:BMI Distinguished Seminar // Mario Penzo: Neural mechanisms govern
 ing the learning and execution of avoidance behavior
DTSTART:20240619T121500
DTEND:20240619T131500
DTSTAMP:20260405T204923Z
UID:7871532e17d2c55e616006ed84005a1208d74e2f0d0e1ab702a01aed
CATEGORIES:Conferences - Seminars
DESCRIPTION:Mario Penzo\, National Institute of Mental Health\, Bethesda\,
  USA\nThe nervous system orchestrates adaptive behaviors by intricately co
 ordinating responses to internal cues and environmental stimuli. This invo
 lves integrating sensory input\, managing competing motivational states\, 
 and drawing on past experiences to anticipate future outcomes. While tradi
 tional models attribute this complexity to interactions between the mesoco
 rticolimbic system and hypothalamic centers\, the specific nodes of integr
 ation have remained elusive. Recent research\, including our own\, sheds l
 ight on the midline thalamus's overlooked role in this process. We propose
  that the midline thalamus integrates internal states with memory and emot
 ional signals to guide adaptive behaviors. Our investigations into midline
  thalamic neuronal circuits have provided crucial insights into the neural
  mechanisms behind flexibility and adaptability. Understanding these proce
 sses is essential for deciphering human behavior and conditions marked by 
 impaired motivation and emotional processing. Our research aims to contrib
 ute to this understanding\, paving the way for targeted interventions and 
 therapies to address such impairments.\n\nRecent papers:\n\nGao\, C.\, Len
 g\, Y.\, Ma\, J.\, Rooke\, V.\, Rodriguez-Gonzalez\, S.\, Ramakrishnan\, C
 .\, Deisseroth\, K.\, and Penzo\, M.A. (2020). Two genetically\, anatomica
 lly and functionally distinct cell types segregate across anteroposterior 
 axis of paraventricular thalamus. Nat. Neuroscience 23\, 217-228.\n\nMa\, 
 J.\, du Hoffmann\, J.\, Kindel\, M.\, Beas\, B.S.\, Chudasama\, Y.\, and P
 enzo\, M.A. (2021). Divergent projections of the paraventricular nucleus o
 f the thalamus mediate the selection of passive and active defensive behav
 iors. Nat. Neuroscience 24\, 1429-1440.\n\nGao\, C.\, Gohel\, C.A.\, Leng\
 , Y.\, Ma\, J.\, Goldman\, D.\, Levine\, A.J.\, and Penzo\, M.A. (2023). M
 olecular and spatial profiling of the paraventricular nucleus of the thala
 mus. eLife 12.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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