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SUMMARY:"Photochemistry\, Organocatalysis & Enzymes: New Radical Opportuni
 ties
DTSTART:20240124T161500
DTEND:20240124T171500
DTSTAMP:20260502T061158Z
UID:0a36649b1fa04002009c650c27bdd49c86ba64dac547d70af7d374b1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Paolo Melchiorre\, University of Bologna\, Industria
 l Chemistry Department\nThe chemical reactivity of electronically excited 
 molecules differs fundamentally from that in the ground state. This is the
  underlying reactivity concept of photochemistry\,1 which has traditionall
 y allowed the development of unique chemical transformations not achievabl
 e via conventional ground-state pathways. For example\, an excited-state m
 olecule is both a better electron-donor (i.e. a better reductant) and elec
 tron-acceptor (i.e. a better oxidant) than in the ground state. This expla
 ins why light excitation of organic molecules can unlock unconventional re
 activity manifolds. \nIn this context\, our laboratory has been exploring 
 the potential of some organocatalytic intermediates to directly reach an e
 lectronically excited state upon visible-light absorption to then switch o
 n novel catalytic functions that are unavailable to ground-state organocat
 alysis.2 A similar photo-activation principle can be applied to enzyme-bou
 nd organocatalytic intermediates to trigger non-natural radical processes 
 within an active site. These photochemical approaches allowed us to expand
  the synthetic possibilities offered by the excited-state reactivity of or
 ganocatalytic intermediates and to develop enantioselective radical proces
 ses for which there is no general solution with established methods.\n\n\n
 References:\n[1]         V. Balzani\, P. Ceroni\, A. Juris\, Eds. 
 in Photochemistry and Photophysics\, Wiley-VCH\, 2014.\n[2]       
   M. Silvi\, P. Melchiorre\, Nature 2018\, 554\, 41–49.\n 
LOCATION:BCH 2201
STATUS:CONFIRMED
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