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SUMMARY:BMI Distinguished Seminar // Tom Mrsic-Flogel: Decision Making: Fr
 om Brain-Wide Dynamics to Multi-regional Circuit Mechanisms
DTSTART:20250205T121500
DTEND:20250205T131500
DTSTAMP:20260510T164653Z
UID:2ac1944e733477c0d48fd0aaca86eca763d5b8268a723e72435d902b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Tom Mrsic-Flogel\, UCL\, UK\nThroughout our lives we make coun
 tless decisions based on learned associations between sensory inputs and b
 eneficial actions. However\, flexible behaviour requires that these learne
 d associations only influence our actions when they serve our current goal
 s. While frontal cortex is known to be critical for this behavioural flexi
 bility by representing internal goals and context-dependent rules\, and th
 e basal ganglia are essential for implementing learned sensorimotor associ
 ations\, the mechanisms by which frontal regions exert control over these 
 action selection circuits remain poorly understood. Using brain-wide recor
 dings in mice\, we demonstrate that learning establishes distributed senso
 rimotor transformations\, enabling sustained representations of relevant s
 ensory information in premotor regions of frontal-motor cortex\, thalamus\
 , basal ganglia\, midbrain and cerebellum. Neural dynamics in these region
 s couple sensory evidence to movement preparation while remaining distinct
  from movement execution. At the circuit level\, targeted activity manipul
 ations and recordings reveal that the anterior tip of secondary motor cort
 ex (atMOs) implements “cognitive control” through an activity 'state c
 lamping' mechanism\, dynamically controlling population dynamics in the st
 riatum to enable goal-directed sensorimotor mapping. This mechanism operat
 es in a neural dimension orthogonal to evidence accumulation\, allowing pr
 ecise control over whether sensory evidence leads to action. Together\, th
 ese findings reveal how brain-wide dynamics coordinate with multi-regional
  circuit mechanisms to selectively engage learned sensorimotor transformat
 ions according to current behavioral goals.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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