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SUMMARY:Chemical and Computational Proteomics for Functional Target Discov
 ery
DTSTART:20240115T160000
DTEND:20240115T170000
DTSTAMP:20260410T063552Z
UID:be69929a4ee8594f36cd870a840be12205a78b0a98fdf8ef4832052e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Chu Wang\, College of Chemistry and Molecular Engineerin
 g\, Peking University\, Beijing (China)\nBIOENGINEERING SEMINAR\n \nAbstr
 act:\nGenome sequencing projects have revolutionized our view of the compl
 exity of prokaryotic and eukaryotic proteomes\, however\, we are also left
  with a daunting challenge of functionally annotating these large number o
 f predicted proteins. Chemical proteomic methods\, such as activity-based 
 protein profiling (ABPP)\, have been developed aiming at systematically di
 scovering new functional targets directly from native proteomes. In this t
 alk\, I will present recent progresses from my laboratory which combine AB
 PP-based chemical proteomic\, biochemical and computational strategies to 
 uncover the functional targets of ligand/cofactor binding and post-transla
 tional modifications in proteomes.\n\nBio:\nChu Wang received Ph.D. in 200
 7 from University of Washington under the guidance of Professor David Bake
 r\, training in the area of computational protein structural prediction an
 d design. He then worked as a postdoctoral fellow with Professor Benjamin 
 Cravatt at The Scripps Research Institute\, Lo Jolla\, and developed multi
 ple chemical proteomic methods to profile reactive cysteines and modificat
 ions in proteomes. In 2014\, he joined Peking University to start his inde
 pendent career and was promoted to tenured professor of Chemical Biology i
 n 2020. He has won Young Chemical Biologist Award from International Chemi
 cal Biology Society and Distinguished Young Scholar Award from National Na
 tural Science Foundation of China. His research interest is to develop che
 mical and computational proteomics methods to enable quantitative profilin
 g of functional enzymes\, protein post-translational modifications as well
  as protein-ligand interactions in proteomes.\n\n\n\nZoom link for attendi
 ng remotely: https://epfl.zoom.us/j/62383401524\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/62383401524
STATUS:CONFIRMED
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