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SUMMARY:Regulation of T cell fate diversity
DTSTART:20240118T133000
DTEND:20240118T143000
DTSTAMP:20260428T021523Z
UID:d450206703821ff0d310cdd0409590f55247e4f1caef0743e85a3853
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Annette Oxenius\, PhD\nInstitute of Microbiology\, ETH Z
 urich\, Switzerland\nAbstract: \n\nRobust and heterogeneous antigen-speci
 fic CD8 T cell responses are essential for effective host defense against 
 infection. Upon an acute viral infection\, a single activated naïve CD8 T
  cell can give rise to progeny comprising both early precursors of effecto
 r and memory cells. How such heterogeneity is generated on a mechanistic l
 evel is still not well resolved. Different models propose various factors 
 or mechanisms that contribute to the establishment of cellular heterogenei
 ty\, including the strength of initial T cell receptor (TCR) signaling and
  asymmetric cell division (ACD). In both models\, the immunological synaps
 e (IS)\, formed between the antigen-presenting cell (APC) and the engaged 
 T cell\, orchestrates TCR activation and establishes a polarization axis s
 erving as a prerequisite for ACD. ACD is characterized by a polarized dist
 ribution of specific fate-determining transcription factors\, cell organel
 les and surface receptors. However\, a direct link of ACD to subsequent as
 ymmetric fate on a single cell level is missing. We established experiment
 al systems allowing to follow the fate of single daughter cell progenies i
 nduced by weak or strong TCR stimulation using live imaging. Our results i
 ndicate a role for ACD in fate determination\, specifically after strong T
 CR stimulation. \n\nBiography:\nProf. Annette Oxenius\, PhD\, received her
  university degree in biochemistry and molecular biology at the University
  of Zurich in 1993 and in 1997 she completed her PhD in immunology at the 
 Institute of Experimental Immunology at ETH Zurich. After a postdoc at the
  University of Oxford\, UK\, she was elected assistant professor for immun
 ology at the Institute of Microbiology of the ETH in 2002\, was promoted t
 o associate professor in 2007 and to full professor in 2012. Her research 
 focuses on the regulation of immune responses in the context of acute and 
 persistent viral infections in experimental mouse models.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/68007218949
STATUS:CONFIRMED
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