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SUMMARY:BMI Seminar // Nick Robinson: Hippocampal sequences in temporal as
 sociation memory and information transfer
DTSTART:20240125T170000
DTEND:20240125T180000
DTSTAMP:20260510T040518Z
UID:20295cb5a217a7a5471fffa6148f55a64989a0722c1559511547c48d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nick Robinson\, The University of Edinburgh\, UK\nI will brief
 ly present two projects which utilize the combination of targeted optogene
 tics and 2-photon calcium imaging to explore the role of hippocampal activ
 ity sequences in the formation of episodic memories and their importance f
 or the transmission of information to downstream brain regions. Associati
 ng events across time is essential for the formation of episodic memories.
  The hippocampus may support this ability by generating neural activity se
 quences which facilitate the encoding of new experiences. Using two-photon
  calcium imaging\, we recorded CA1 activity sequences in mice during an ol
 factory delayed paired-associates task. Sequences tiled the delay more eve
 nly in running mice and reorganized across learning\, progressively tiling
  the delay more evenly\, which correlated with faster learning of new asso
 ciations. Next\, we utilized holographic two-photon optogenetics to drive 
 sequences across the delay during learning. Photostimulation revealed a su
 ppressive surround functional connectivity profile in CA1 and led to impri
 nting of stimulated neurons into the endogenous sequences\, causing photoa
 ctivated neurons to encode the new experience. Determining how specific f
 eatures of neural activity patterns are utilized by downstream circuits re
 quires the ability to perform targeted manipulations with high-fidelity do
 wnstream readout. We developed a strategy combining all-optical interrogat
 ion with simultaneous high density electrophysiological recordings from mu
 ltiple brain areas in awake mice. We use this approach to demonstrate that
  the temporal order of optogenetically driven place cell reactivation sequ
 ences differentially impacts activity downstream.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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