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SUMMARY:Mechano-Sensing Biomolecular Systems
DTSTART:20240123T160000
DTEND:20240123T170000
DTSTAMP:20260413T212245Z
UID:5be6915ae29fa7b03b2cd128808f4807dcf694a4cf9cda6d8fd5c22b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Frauke Gräter\, Molecular Biomechanics group (MBM)\, He
 idelberg Institute for Theoretical Studies (DE)\nBIOENGINEERING SEMINAR\n
  \nAbstract:\nNature has evolved sophisticated molecular systems that sen
 se mechanical force. They do so by specifically responding to the external
  force by a structural change or mechanochemical reaction. I will showcase
  systems inside and outside of the biological cell to highlight basic prin
 ciples of molecular mechano-sensing and how one can engineer or mimic such
  systems. Examples will include protein activation by stretching forces an
 d our recent discovery of mechanoradicals in collagen. We find protein mec
 hanoradicals\, just as their polymer analogues known for already a century
 \, to translate mechanical into oxidative stress\, as a new mode of mechan
 o-sensing in biology.\n\nBio:\nFrauke Gräter is group leader of the Molec
 ular Biomechanics group (MBM) at HITS and Professor for Molecular Biomecha
 nics at Heidelberg University. She studied chemistry in Tübingen\, Kyoto 
 and Heidelberg and did her Ph.D. at the Max Planck Institute for Biophysic
 al Chemistry\, Göttingen\, Germany\, in 2005. After postdoc positions\, a
 mong them at Columbia University\, New York\, USA\, she became leader of a
  junior group in Shanghai\, China\, at the partner institute of the Chines
 e Academy of Sciences and the Max Planck Society. Since 2009\, Frauke Grä
 ter has been group leader of the Molecular Biomechanics (MBM) group at HIT
 S. Additionally\, she became professor for molecular biomechanics at Heide
 lberg University in 2014\, and from 2017 until 2020 she was member of the 
 board of directors at the Interdisciplinary Center for Scientific Computin
 g (IWR) at Heidelberg University. She served as Scientific Director of HIT
 S from 2021-2022. The major interest of Frauke Gräter and her Molecular B
 iomechanics group is to decipher how proteins have been designed to specif
 ically respond to mechanical forces in the cellular environment or as a bi
 omaterial. For this purpose\, they use high performance computing (HPC) an
 d simulation techniques on different scales. In her research\, Frauke Grä
 ter covers medicine topics like blood clotting as well as materials scienc
 e on spider silk or collagen.  For her outstanding impact on HPC research
 \, Frauke Gräter was awarded PRACE Ada Lovelace Award for HPC. In 2020\, 
 she received an ERC Consolidator Grant awarded by the European Research Co
 uncil. As of 2021\, she is a member of the Editorial Board of the “Bioph
 ysical Journal”. She is visiting professor at EPFL from 2023-2024.\n\n\n
 \nZoom link for attending remotely: https://epfl.zoom.us/j/67706983281\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/67706983281
STATUS:CONFIRMED
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