BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Investigating and Manipulating Neurodegeneration-Related Protein O
 ligomers Using Nanopore and X-ray Techniques
DTSTART:20240208T140000
DTEND:20240208T150000
DTSTAMP:20260930T195016Z
UID:256676c9c86f44f182ec1fe9a9c1109752894ffe06c469347a28490e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jinghui Luo received his Ph.D. degree in 2014 from Leiden Univ
 ersity under the supervision of Prof. Jan Pieter Abrahams. After postdocto
 ral research with Prof. Hagan Bayley at Oxford University\, he started his
  independent career at the Paul Scherrer Institute and then obtained his t
 enure in 2022.\n\nProtein oligomers\, pivotal in both physiological and pa
 thological processes such as Alzheimer’s disease\, present challenges in
  comprehending their intricate intermediate and diverse structures. Our re
 search leverages specialized biological nanopore approaches and X-ray tech
 niques to explore and manipulate protein oligomers in diverse settings\, r
 anging from in vitro to in vivo. We have engineered a stable Alzheimer’s
  Aβ42-oligomer mimic on the α-hemolysin (αHL) nanopore for drug develop
 ment and investigated the conformational kinetics and trapping of Parkinso
 n’s α-Syn in an αHL nanopore for small compound screening. Additionall
 y\, our nanopore sensing probes reveal LL-37 fragments' oligomeric equilib
 rium correlated with antimicrobial effects.\n\nTo impede toxic oligomer fo
 rmation\, we employed molecular glues to evaluate the trapping and degrada
 tion potential of amyloid clusters in C.elegans. Our time-resolved small a
 ngle X-ray scattering and C.elegans experiments provide insights into the 
 in vivo and in vitro condensation of tau and α-synuclein in the presence 
 of molecular glues. Furthermore\, we observed the conversion of metal ions
  into metallic nanoparticles induced by amyloid clusters by using scanning
  transmission X-ray microspectroscopy. Looking ahead\, the integration of 
 nanopore and X-ray techniques holds great promise for advancing our unders
 tanding of neurodegeneration-related oligomers\, offering valuable insight
 s for therapeutic development.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR