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SUMMARY:From post-translational modification to drug discovery
DTSTART:20240425T101500
DTEND:20240425T113000
DTSTAMP:20260315T145807Z
UID:34f92d831c91ff03ebc9562c5c1e8fac58350474a00fe7478cb07340
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Edward Tate - Imperial Collegue of London\nThe Tate lab d
 evelops novel chemical biology approaches to enable drug discovery against
  post-translational modification (PTM) pathways and intractable drug targe
 ts\, including chemical proteomic target identification\, screening techno
 logies\, and chemical probe discovery for protein-protein interactions and
  enzymes modulating PTMs. Recent highlights include the first cell-active 
 activity-based probes (ABPs) for deubiquitinases (DUBs)\, new tools for an
 alysis and discovery of pathogenic secreted protease activities\, and the 
 first comprehensive maps of specific classes of protein lipidation PTM thr
 ough chemical proteomics. We are also interested in new modalities includi
 ng antibody-PROTAC conjugates\, and translation of drug candidates.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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