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SUMMARY:Detecting Death and Damage\; Understanding Inflammatory Cell Migra
 tion in vivo
DTSTART:20240213T121500
DTEND:20240213T131500
DTSTAMP:20260407T110726Z
UID:84af5207e57b2f63a5ed77b5a84a2eccaa39b66dedab7f76b8c0fc8d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Will Wood\, Institute for Regeneration and Repair\, University
  of Edinburgh\nA critical early wound response is the recruitment of infla
 mmatory cells drawn by danger cues released by the damaged tissue.  Hydro
 gen peroxide has been identified as the earliest wound attractant in Droso
 phila and Zebrafish and we have shown using fly embryos that laser woundin
 g triggers an instantaneous calcium flash in the epithelium which in turn 
 activates the NADPH oxidase DUOX to generate Hydrogen Peroxide.  As a con
 sequence of hydrogen peroxide production\, macrophages (hemocytes) within 
 the fly embryo rapidly migrate toward the wound site powered by the format
 ion of dynamic actin-rich lamellipodia.  We use live imaging to understan
 d the mechanism by which inflammatory cells are able to detect H2O2 and ge
 nerate the dynamic actin-rich structures necessary for their migration.  
 We are particularly interested in how immune cells are able to prioritise 
 competing cues such as wound induced damage signals and ‘eat me’ cues 
 from apoptotic corpses and how exposure to one of these signals influences
  the cells ability to respond to subsequent cues.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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