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SUMMARY:The Michael J. Fox Foundation - Therapeutics Pipeline Program
DTSTART;VALUE=DATE:20240516
DTSTAMP:20260510T105119Z
UID:56b9364a7f9322172212c9328c47b0d1582eda4034243b9e262f0ba8
CATEGORIES:Call for proposal
DESCRIPTION:Aim:  The Parkinson’s Disease Therapeutics Pipeline Program
  advances therapeutic development through pre-clinical and/or into clinica
 l testing of approaches addressing unmet needs of people with PD with clea
 r potential to prevent\, stop\, or delay disease progression or to reduce 
 the burden of daily symptoms. As the requirements for delivering new treat
 ments into the market depend on specialized expertise and resources\, a un
 ique goal of this program is to promote clearer paths to commercialization
  and market access by the PD community. Therefore\, we are only accepting 
 applications from industry groups or academic teams working in collaborati
 on with a dedicated industry partner capable of further commercial develop
 ment of a promising intervention.\n\nMJFF prioritizes pre-clinical and cli
 nical programs that may slow\, stop\, or prevent disease progression\, eff
 orts that address moderate-to-advanced motor or non-motor symptoms of Park
 inson’s not well-managed by current treatments such as advanced gait dis
 turbances (e.g.\, balance issues linked to falls\, freezing) and cognitive
  changes.\n\nFor this program\, MJFF will not consider proposals focused o
 n the following:\n\n	Applications seeking to identify new intervention tar
 gets (e.g.\, large-scale screening or genomic/transcriptomic analyses).\n	
 Applications seeking to validate a target with only tool compounds or biol
 ogical manipulations that have no viable path for further drug optimizatio
 n and development.\n	Applications seeking to test reformulation of commerc
 ially available drugs via a new route of administration.\n	Application see
 king to assess efficacy of dietary supplements.\n\n\nFunding:       f
 rom $250\,000 for smaller\, targeted programs to upwards of $2M for larger
 \, multi-stage preclinical and/or clinical programs\n\nDuration:     
  1 to 2 years for pre-clinical programs\n2 to 3 years for clinical program
 s\n\nEligibility: Applications may be submitted by researchers or clinicia
 ns in:\n \n\n	U.S. and non-U.S. public and private non-profit entities\, 
 such as universities\, colleges\, hospitals\, laboratories\, units of stat
 e and local governments\, and eligible agencies of the federal government 
 in collaboration with biotechnology/pharmaceutical/medical device companie
 s\, or other publicly or privately held for-profit entities.\n	MJFF encour
 ages the inclusion of researchers who span career stages.\n	Early career i
 nvestigators (within 1-7 years of first independent appointment or equival
 ent) are encouraged to apply and are permitted to serve as Principal Inves
 tigator (PI)\; Post-doctoral fellows are permitted to serve as Co-Principa
 l Investigator (Co-PI). Training and fellowship activities are not support
 ed through this program.\n\n\nHow to Apply: The two-stage application proc
 ess begins with an LOI\, which can be submitted on a rolling basis on the 
 MJFF Grant Portal. Instructions for pre-proposal submission vary if submit
 ting a pre-clinical project or a clinical project. Selected applicants wil
 l be notified within three weeks and will be invited to submit a full prop
 osal by one of the four deadlines (see below). Budgets should be formulate
 d to include 15% OH.\n\nDeadlines (full proposals):          \n\
 n\n	11 January 2024\n	14 March 2024\n	16 May 2024\n	27 June 2024\n\n\nFurt
 her information\n\n\n	More information about the program is available here
  and the full RFA is available here\n	Application portal can be found here
 \n	For any other questions\, please contact the Research Office\n
LOCATION:
STATUS:CONFIRMED
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