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SUMMARY:BMI Seminar // Tanya Sippy: “Cell type-specific auditory respons
 es in the auditory striatum are shaped by feed-forward inhibition”
DTSTART:20240620T170000
DTEND:20240620T180000
DTSTAMP:20260510T235333Z
UID:4dfa6dfecbe183c4104e94568c3525f73f8395aa86284ed6a3e03229
CATEGORIES:Conferences - Seminars
DESCRIPTION:Tanya Sippy\, New York University Grossman School of Medicine\
 , New York\, USA\nThe posterior “tail” region of the striatum (pStr) r
 eceives dense innervation from sensory brain regions and has been demonstr
 ated to play a role in behaviors that require sensorimotor integration inc
 luding discrimination\, avoidance and defense responses. The output neuron
 s of the striatum\, the D1 and D2 striatal projection neurons (SPNs) that 
 make up the direct and indirect pathways\, respectively\, are thought to p
 lay differential roles in these behavioral responses\, although it remains
  unclear if or how these neurons display differential responsivity to sens
 ory stimuli. In my talk\, I will first present data from my lab in which w
 e utilized whole-cell recordings in vivo and ex vivo to examine the streng
 th of excitatory and inhibitory synaptic inputs onto D1 and D2 SPNs follow
 ing the stimulation of upstream auditory pathways. We found that auditory 
 evoked D1 SPN responses were stronger than those of D2 SPNs\, and that thi
 s was due to a cell-type specific difference in feed forward inhibition. I
  will then present unpublished two photon (2P) calcium imaging data from o
 ur lab examining how cell type specific responses in the pStr change with 
 learning\, and how this corresponds with changes in presynaptic (axon) act
 ivity from primary auditory regions\, while mice perform an auditory go/no
 -go task.\n 
LOCATION:SV 2510 https://plan.epfl.ch/?room==SV%202510 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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