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SUMMARY:BMI Seminar // Omer Bayraktar: Mapping the rules of glioblastoma w
 ith integrated single cell and spatial genomics
DTSTART:20240229T150000
DTEND:20240229T160000
DTSTAMP:20260427T204625Z
UID:5394d66d4b9729b1f1b5193613d86335033985704f6a14f22408bf00
CATEGORIES:Conferences - Seminars
DESCRIPTION:Omer Bayraktar\, Wellcome Sanger Institute\, Hinxton\, UK\nThe
  malignant brain tumour glioblastoma multiforme (GBM) displays significant
  levels of cellular heterogeneity and plasticity that correlate with patie
 nt outcomes. However\, we lack fundamental insight on how diverse malignan
 t cell states arise and organise in GBM. Here\, I will present GBM-space\,
  a new collaborative effort to map the cellular and tissue architecture of
  GBM using multi-modal genomics. Deeply profiling 12 tumours across multip
 le sites\, we created the most comprehensive single cell and spatial genom
 ic map of inter- and intratumour heterogeneity to date. Surveying joint RN
 A and ATAC profiles of over 1 million cells\, we expanded the description 
 of recurrent malignant and TME cell states and resolved their gene regulat
 ory networks. Using sequencing and imaging-based spatial transcriptomics\,
  we discovered that malignant cell states regionally segregate into distin
 ct spatial tissue niches in GBM and associate with distinct TMEs. We found
  that these niches recur across patients and tumour genotypes\, reflecting
  a shared tissue organisation across GBM. Furthermore\, we find that that 
 the spatial organisation of malignant cells reflects their stereotyped cel
 lular trajectories from neurodevelopmental-like to injury response and hyp
 oxia states. Our efforts reveal novel spatial organisation of malignant ce
 ll states in glioblastoma across a dominant cellular trajectory.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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