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SUMMARY:Engineering Bacteria as Living Drug Delivery Systems
DTSTART:20240226T141500
DTEND:20240226T151500
DTSTAMP:20260930T213415Z
UID:0a38475bccb2b43f2a26e8d7487a88d9719dae6a4b04c30532f919f2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Tetsuhiro Harimoto\, Ph.D.\, Postdoctoral Fellow\, Mooney Lab\
 , Harvard University\, Boston\, MA (USA)\nBIOENGINEERING SEMINAR\n \nAbst
 ract:\nEngineered living cells as therapeutic agents are transforming mode
 rn medicine. An emerging focus is tumor-colonizing bacteria\, where syste
 mically delivered bacteria have been demonstrated to selectively grow with
 in solid tumors. This natural tropism to tumors presents a unique opportu
 nity to engineer bacteria as programmable drug delivery vehicles to region
 s inaccessible with existing chemo- and immuno-therapeutics. In this talk
 \, I will describe our recent efforts to enhance bacterial cancer therapie
 s through synthetic biology. I will focus on strategies to address several
  key challenges for clinical translation\, including bacterial delivery\, 
 therapeutic identification\, and off-target toxicity. Our multidisciplinar
 y approach\, spanning from gene circuit design to in vitro and in vivo
  models\, advances bacteria as next-generation drug carriers capable of s
 ensing and responding to diseases within the body.\n\nBio:\nPh.D.\, Biomed
 ical Engineering\, Columbia University (2022)\nB.S.\, Pharmacology & Toxic
 ology\, University of Toronto (2014)\n\n\nZoom link for attending remotely
 \, if needed: https://epfl.zoom.us/j/68848415101
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/68848415101
STATUS:CONFIRMED
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