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SUMMARY:Cell Size and Ploidy: From Single Cells to the Physiology of Verte
 brate Embryos
DTSTART:20240228T091500
DTEND:20240228T101500
DTSTAMP:20260406T203418Z
UID:ffc8f25934da0c2928d386a2f5f91e7779912c141f2adfac76fad4b9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Clotilde Cadart\, Ph.D.\, Group Leader\, Institut Cochin\, Par
 is (FR)\nBIOENGINEERING SEMINAR\n \nAbstract:\nCell size correlates posit
 ively with DNA content both within species as a function of ploidy (i.e. g
 enome copy number) and across species as a function of genome size yet the
  impacts on cellular and organismal physiology are poorly understood. Xeno
 pus frogs are ideal for exploring this question since their genome size va
 ries widely across species and ploidy can be manipulated within a species.
  During my postdoctoral work (UC Berkeley\, Pr. Heald’s lab)\, I found t
 hat triploid X. laevis and X. borealis tadpoles of identical mass to diplo
 ids consist of fewer\, larger cells and consume oxygen at a lower rate. Co
 mparison with a dodecaploid species\, X. longipes\, revealed that metaboli
 c differences emerged during development only when cell size began to scal
 e with genome size. These findings suggest that genome size affects metabo
 lism through changes in cell size and that less energy is required to sust
 ain larger cells within the same multicellular organism. In future work\, 
 my research will combine experiments on single cells and Xenopus embryos t
 o understand how cell and genome size/ploidy affect the physiology and evo
 lution of multicellular organisms.\n\nBio:\n2024 - Present    Junior G
 roup Leader\, Institut Cochin\, Paris (FR)\n2018 - 2023    Postdoctora
 l Researcher\, University of California\, Berkeley (USA)\n2013 - 2018  
   Ph.D.\, Institut Curie\, Paris (FR)\n2012 - 2013    Master's degre
 e\, Biophysics\, Université Paris Cité\, Paris (FR)\n2009 - 2012    
 study of Medicine\, Université Claude Bernard Lyon 1 (FR)\n\n\nZoom link 
 for attending remotely\, if needed: https://epfl.zoom.us/j/67478649238
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/67478649238
STATUS:CONFIRMED
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