BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:MechE Colloquium: Nanofluidics - Exploring new frontiers DTSTART:20240409T120000 DTEND:20240409T130000 DTSTAMP:20260510T022645Z UID:e589a63cb5ae07f1e78cf3dcf35375f799fa75f883d0113a1b2ed6df CATEGORIES:Conferences - Seminars DESCRIPTION:Prof Aleksandra Radenovic\, EPFL STI LBEN\nAbstract: \n\nIn this talk\, I will describe a novel single-molecule method where we engine er precise spatial and temporal control into the single-molecule experimen t. We use a glass nanopore mounted on a 3D nanopositioner to spatially sel ect molecules\, deterministically tethered on a glass surface\, for contro lled translocations. By controlling the distance between the nanopore and the glass surface\, we can actively select the region of interest on the m olecule and scan it a controlled number of times and at a controlled veloc ity. Decreasing the velocity and averaging thousands of consecutive readin gs of the same molecule increases the signal-to-noise ratio (SNR) by two o rders of magnitude compared to free translocations. We applied our method to various DNA constructs\, achieving down to single nucleotide gap resolu tion. The spatial multiplexing combined with the sub-nanometer resolution could be used in conjunction with micro-array technologies to enable the s creening of DNA\, improving point-of-care devices\, or enable high-density \, addressable DNA data storage.\nIn the second part of the talk I will in troduce two novel types of nanofluidic platforms. The geometry of the firs t nanofluidic platform combines the benefits of reduced sensing regions ty pically seen in 2D material nanopores with the asymmetric geometry of capi llaries\, resulting in ionic selectivity\, stability\, and scalability. Th e proposed nature-inspired growing method provides a flexible nanopore pla tform for various nanofluidic research applications\, such as biosensing\, energy science\, and filtration technologies.\nThe second nanofluidic pla tform with a large entrance asymmetry is designed for in-memory processing \, which can be mass-produced and behaves as performant memristive charge threshold switches with discontinuous current-voltage characteristics. The device's performance and reliability enabled the building of a logic circ uit composed of two interactive ionic channels and an electronic resistor\ , which opens the way to the design of nanofluidic neural networks for bra in-inspired ionic computations.\n\n1. Leitao\, S.M.\, Navikas\, V.\, Miljk ovic\, H.\, Drake\, B.\, Marion\, S.\, Pistoletti Blanchet\, G.\, Chen\, K .\, Mayer\, S.F.\, Keyser\, U.F.\, Kuhn\, A. and Fantner\, G.E.\, Radenovi c A. 2023. " Spatially multiplexed single-molecule translocations through a nanopore at controlled speeds. " Nature Nanotechnology\, pp.1-7.\n2. Che rnev\, Andrey\, Yunfei Teng\, Mukeshchand Thakur\, Victor Boureau\, Lucie Navratilova\, Nianduo Cai\, Tzu‐Heng Chen\, Liping Wen\, Vasily Artemov\ , and Aleksandra Radenovic. 2023 "Nature‐Inspired Stalactite Nanopores f or Biosensing and Energy Harvesting." Advanced Materials 2302827.\n3. Emme rich\, Theo\, Yunfei Teng\, Nathan Ronceray\, Edoardo Lopriore\, Riccardo Chiesa\, Andrey Chernev\, Vasily Artemov\, Massimiliano Di Ventra\, Andras Kis\, and Aleksandra Radenovic. 2023. "Ionic logic with highly asymmetric nanofluidic memristive switches." arXiv preprint arXiv:2306.07617 \n\n\nB iography: \n\nProf. Aleksandra Radenovic is a full professor of biologica l engineering at the École Polytechnique Fédérale de Lausanne (EPFL) an d head of the Laboratory of Nanoscale Biology.\nHer lab works in the resea rch field that can be termed single-molecule biophysics. She has received her Ph.D. in Biophysics from the University of Lausanne (Switzerland.) in 2003 and a Msc. in Physics from the University of Zagreb (Croatia) in 2000 . In 2010. she received a European Research Council (ERC) Starting Grant i n 2010 and SNF Backup scheme Consolidator Grant (2015). She is also the re cipient of the CCMX materials challenge award in 2016 and the Advanced ERC (2020) grant.\nShe develops techniques and methodologies based on optical imaging\, bio-sensing and single-molecule manipulation with the aim to mo nitor the behavior of individual biological molecules and complexes in vit ro and in live cells.\n\n\n\n  LOCATION:MED 0 1418 https://plan.epfl.ch/?room==MED%200%201418 https://epf l.zoom.us/j/61626448592 STATUS:CONFIRMED END:VEVENT END:VCALENDAR