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SUMMARY:ChemBio seminar by Prof. Stephen Renshaw (Sheffield) - CH-635
DTSTART:20240523T161500
DTEND:20240523T171500
DTSTAMP:20261001T181320Z
UID:9c5c6ec03450e8e0687d51ce98262356417c6adc23d3293def8f54cb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Stephen Renshaw\nTitle: Zebrafish models of innate immun
 ity\n\nAbstract:\nZebrafish are emerging as an excellent model for the stu
 dy of innate immunity. Zebrafish larvae have neutrophils and macrophages f
 rom an early age\, without any adaptive immune system. Combined with the t
 ransparency of the larvae and the genetic tractability of the system\, it 
 is possible to image many aspects of innate immune cell biology in vivo. W
 e have exploited this system to broaden our understanding of innate immune
  cell function during infection and inflammatory injury\, with implication
 s for the study of human disease. Our results are applicable to antimicrob
 ial resistant infection and infectious/inflammatory diseases such as COPD 
 and cystic fibrosis.\nIn this talk I will present our history as a pioneer
 ing group using the zebrafish model to study innate immunity and show unpu
 blished data from ongoing projects in inflammation and infection.\n\nSpeak
 er's biography:\nI am the Sir Arthur Hall Professor of Medicine at the Uni
 versity of Sheffield and Honorary Consultant Respiratory Physician at Shef
 field Teaching Hospitals NHS Foundation Trust.\nI am currently Head of Div
 ision of Clinical Medicine within the School of Medicine and Population He
 alth leading a division of 450 staff and around 1800 students.\nI am Direc
 tor of the Bateson Centre\, a University Research Centre\, built around ze
 brafish models of disease\, with around 40 PIs and over £20m of active fu
 nding.\nI am also Deputy Faculty Director of Research and Innovation in th
 e Faculty of Health\, and Faculty REF lead (REF is our Research Excellence
  Framework\, a 7 yearly assessment of research performance that determines
  a large part of the University income).\nI studied undergraduate medicine
  at the University of Cambridge and clinical medicine at Oxford University
  Medical School. After a clinical rotation in Nottingham\, I moved to Shef
 field to take up a Wellcome Trust Clinical Research Training Fellowship\, 
 to complete a PhD on the regulation of neutrophil lifespan with Professor 
 Moira Whyte.\nAfter 3 years as Clinical Lecturer in Respiratory Medicine\,
  I was awarded an MRC Clinician Scientist Fellowship to use zebrafish to s
 tudy inflammation resolution. In 2008 I was awarded an MRC Senior Clinical
  Fellowship and in 2014 an MRC Programme Grant to continue this work.\n I
  continue clinical work in Respiratory Medicine with a special interest in
  Interstitial Lung Disease associated with multisystem inflammatory diseas
 e (sarcoidosis and connective tissue disease predominantly).\n\n\nLab webs
 ite: https://renshaw.sites.sheffield.ac.uk/home\n\n 
LOCATION:CE 1 2 https://plan.epfl.ch/?room==CE%201%202
STATUS:CONFIRMED
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