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SUMMARY:EPFL BioE Talks SERIES  "Building the Human Lungs: Lessons From Or
 ganoids and Gene Editing"
DTSTART:20240429T121500
DTEND:20240429T131500
DTSTAMP:20260528T175108Z
UID:7a105cc6cffff5f8a50a7362ecc710825c8fd3b5bfe9b39bb48b2747
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Emma Rawlins\, Gurdon Institute and Department of Physio
 logy\, Development and Neuroscience\, University of Cambridge (UK)\nWEEKLY
  EPFL BIOE TALKS SERIES (sandwiches provided)\n\nAbstract:\nOrganoids deri
 ved from primary human tissues retain key functional characteristics of th
 e tissue of interest and have the potential to improve in vitro assays use
 d for disease modelling and drug development. However\, the burgeoning CRI
 SPR toolkits have not yet been widely applied to human organoids. We have 
 developed efficient methodologies for the use of CRISPR techniques in prim
 ary human embryonic lung organoids. These will be widely adaptable to othe
 r human organoid systems and include homology directed repair\, CRISPRi\, 
 CRISPRa and drop-out screens. This talk will illustrate how we have applie
 d these systems to develop new human lung organoid models for fundamental 
 developmental biology and disease research. These tools have allowed us to
  identify new cell states and crucial cell communication events underlying
  lung morphogenesis\, as well as model genetic forms of human lung disease
 .\n\n\nBio:\nEmma Rawlins obtained her PhD in developmental biology from t
 he University of Edinburgh in 2002. For her PhD she worked with Dr Andrew 
 Jarman on cell fate specification in the developing Drosophila PNS. She pe
 rformed postdoctoral work with Prof. Brigid Hogan at Duke University from 
 2004 – 2009 where she identified stem cell populations in the developing
 \, homeostatic and repairing mouse lungs. In 2009 she started her lab at t
 he Gurdon Institute\, University of Cambridge and in 2020 was promoted to 
 Senior Group Leader. Emma is also an Associate Professor in the Department
  of Physiology\, Development and Neuroscience. Her lab works on lung stem 
 and progenitor cell biology\, combining innovative human organoid models w
 ith mouse genetics.\n\n\nZoom link (with one-time registration for the who
 le series) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nI
 nstructions for 1st-year Ph.D. students who are under EDBB’s mandatory s
 eminar attendance rule:\nIN CASE you cannot attend in-person in the room\,
  please make sure to\n\n	send D. Reinhard a note well ahead of time (ideal
 ly before seminar day)\, informing that you plan to attend the talk online
 \, and\, during seminar:\n	be signed in on Zoom with a recognizable user n
 ame (not any alias making it difficult or impossible to identify you).\n\n
 Students attending the seminar in-person should collect a confirmation sig
 nature after the talk - please print your own signature sheet beforehand (
 71 kB pdf available for download here). IMPORTANTLY: hang on to this sheet
  as no signature record is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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