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SUMMARY:EPFL BioE Talks SERIES  "Reciprocal Activity as Constraints on the
  Biological Production of Work"
DTSTART:20240527T121500
DTEND:20240527T131500
DTSTAMP:20260510T235152Z
UID:034b08877b653c8a3927d4bd107dc07ff4e026e22e6c4699519aee5b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Michael Murrell\, Laboratory for Living Matter\, Systems
  Biology Institute\, Yale University\, New Haven\, CT (US)\nWEEKLY EPFL BI
 OE TALKS SERIES (sandwiches provided)\n\nAbstract:\nOn small length-scales
 \, the mechanics of soft materials may be dominated by their interfacial p
 roperties as opposed to their bulk properties.  These effects are describ
 ed by equilibrium models of elasto-capillarity and wetting.  In these mod
 els\, interfacial energies and bulk material properties are held constant.
   However\, in biological materials\, including living cells and tissues\
 , these properties are not constant\, but are ‘actively’ regulated and
  driven far from thermodynamic equilibrium.  As a result\, the constraint
 s on work produced during the various physical behaviors of the cell are u
 nknown.  Here\, by measurement of elasto-capillary effects during cell ad
 hesion\, growth and motion\, we demonstrate that interfacial and bulk para
 meters violate equilibrium constraints and exhibit anomalous effects\, whi
 ch depend upon a distance from equilibrium.  However\, their anomalous pr
 operties are reciprocal\, and thus in combination reliably define energeti
 c constraints on the production of work arbitrarily far from equilibrium.
   These results provide basic principles that govern biological assembly 
 and behavior.\n\n\nBio:\nMichael Murrell received his BS at Johns Hopkins 
 University\, and his PhD at MIT.  He then had a joint postdoctoral fellow
 ship between the Institute for Biophysical Dynamics at the University o
 f Chicago\, and the Institut Curie\, in Paris\, France. He now runs the L
 aboratory for Living Matter within the Systems Biology Institute at the
  Yale West Campus\, as part of the Biomedical Engineering and Physics De
 partments.  His laboratory studies the non-equilibrium properties of bi
 ological systems\, as well as designs and engineers novel bio-inspired ma
 terials.  His group comprises a diverse group of experimentalists\, com
 putational scientists and theorists all driven to understand some of the
  most fundamental questions in biophysics\nWhen not in the lab she is in t
 he kitchen experimenting with new protocols a.k.a. recipes or running by t
 he nearest lake.\n\n\nZoom link (with one-time registration for the whole 
 series) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInst
 ructions for 1st-year Ph.D. students who are under EDBB’s mandatory semi
 nar attendance rule:\nIN CASE you cannot attend in-person in the room\, pl
 ease make sure to\n\n	send D. Reinhard a note well ahead of time (ideally 
 before seminar day)\, informing that you plan to attend the talk online\, 
 and\, during seminar:\n	be signed in on Zoom with a recognizable user name
  (not any alias making it difficult or impossible to identify you).\n\nStu
 dents attending the seminar in-person should collect a confirmation signat
 ure after the talk - please print your own signature sheet beforehand (71 
 kB pdf available for download here). IMPORTANTLY: hang on to this sheet as
  no signature record is being kept by anyone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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