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SUMMARY:Functional Proteomics by Induced Proximity
DTSTART:20240624T143000
DTEND:20240624T153000
DTSTAMP:20260510T001449Z
UID:fbd7896c10d0f69e2a1f8f8fff0efce4bed60edf650ea53afab8e938
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Mikko Taipale\, Donnelly Centre for Cellular and Biomedi
 cal Research\, University of Toronto (CAN)\nBIOENGINEERING SEMINAR\n \nAb
 stract:\nTargeted protein degradation and stabilization are promising ther
 apeutic modalities due to their potency\, versatility\, and potential to e
 xpand the druggable target space. However\, only few E3 ligases and DUBs h
 ave been harnessed for this purpose\, significantly limiting the potential
  of the approach. Moreover\, there may be other protein classes that could
  be exploited for this purpose. We established a synthetic proteome-scale 
 platform to functionally identify human proteins that can promote the degr
 adation or stabilization of a target in a proximity-dependent manner. Our 
 results reveal that the human proteome contains a large cache of effectors
  of protein stability\, many of which are more potent than proteins curren
 tly exploited for targeted protein degradation and stabilization. More gen
 erally\, our study highlights proteome-scale induced proximity screens as 
 a powerful platform for functional proteomics.\n\nBio:\nMikko Taipale is a
 n Associate Professor in the Donnelly Centre and the Department of Molecul
 ar Genetics at the University of Toronto. He received his MSc in genetics 
 at the University of Oulu\, Finland (close to the arctic circle). He then 
 joined Asifa Akhtar’s lab in EMBL in Heidelberg\, Germany and completed 
 his PhD on chromatin regulation by histone acetylation. He did his postdoc
 toral training in Sue Lindquist’s lab at the Whitehead Institute. There\
 , he focused on the client recognition mechanisms of Hsp90 chaperone and c
 o-chaperones and on developing high-throughput protein/protein and drug/ta
 rget interactions. Since 2014\, Mikko has had his lab in the Donnelly Cent
 re and the University of Toronto. The Taipale lab is focused on diverse as
 pects of functional proteomics and genomics\, including protein homeostasi
 s\, transcriptional regulation\, disease variant phenotyping\, and host/pa
 thogen interactions.\n\nZoom link for attending remotely: https://epfl.zoo
 m.us/j/63856907146
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/s/63856907146
STATUS:CONFIRMED
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