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SUMMARY:Accelerating protein engineering with viral-based in vivo screenin
 g and evolution technologies - CH636
DTSTART:20240906T160000
DTEND:20240906T170000
DTSTAMP:20260314T203116Z
UID:5ed608e18d84b1d31fb7514088a890aab5698cf02e6220bdeba05d0e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Bryan Dickinson\nAbstract :\nProteins that selectively b
 ind to a target protein of interest are foundational components of researc
 h pipelines\, diagnostics\, and therapeutics. However\, current immunizati
 on-based\, display-based\, and computational approaches for discovering bi
 nders are laborious and time-consuming\, suffer from high false positives\
 , and have a high failure rate. In this presentation\, I will showcase Pro
 tein-Protein Interaction Phage-Assisted Non-Continuous Selection (PPI-PANC
 S)\, a system for comprehensive high-throughput screening of billion+ memb
 er protein variant libraries to isolate high affinity binders to a protein
  in a matter of days. We demonstrate the utility of PPI-PANCS by screening
  multiple protein libraries against a panel of 95 targets and generating d
 ozens of novel binders\, which can then be affinity matured and/or used in
  secondary assays\, such as triggering degradation of endogenous mammalian
  proteins. \n\nBiography:\nBryan Dickinson earned his B.S. in Biochemistr
 y from the University of Maryland in 2005\, and his Ph.D. in Chemistry in 
 2010 from the University of California at Berkeley for work performed unde
 r the supervision of Professor Christopher Chang. He then moved to Harvard
  University as a Jane Coffin Childs Memorial postdoctoral fellow under the
  supervision of Professor David Liu. He joined the faculty at the Universi
 ty of Chicago in the Department of Chemistry in the Summer of 2014\, was p
 romoted to Associate Professor in 2019\, and Professor in 2023.\n\nThe Dic
 kinson Group employs synthetic organic chemistry\, molecular evolution\, a
 nd protein design to develop molecular technologies to study and control c
 hemistry in living systems. The group's current primary research interests
  include: 1) developing new evolution technologies to reprogram and contro
 l biomolecular interactions\, 2) engineering RNA-targeting biotechnologies
  as new therapeutic platforms\, and 3) developing novel proximity-labeling
  chemistries to study biomolecular interactions. Bryan has been recognized
  by multiple prizes and awards\, including the Sloan Foundation Research F
 ellowship\, NSF CAREER Award\, Camille Dreyfus Teacher-Scholar Award\, and
  ACS Chemical Biology Young Investigator Award\, and Bryan was named an In
 vestigator of the Chan Zuckerberg Biohub this year.\n\nLab Website:\nhttps
 ://www.dickinsonlab.uchicago.edu\n\n 
LOCATION:BS 270 https://plan.epfl.ch/?room==BS%20270
STATUS:CONFIRMED
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