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SUMMARY:ChemBio Seminar by Dr. Takeshi Harayama (Institut de Pharmacologie
  Moléculaire et Cellulaire\, Université Côte d’Azur\, France)
DTSTART:20241112T150000
DTEND:20241112T160000
DTSTAMP:20260314T212637Z
UID:8fa24ddc05e061e99ba863ae174ca11326e50f8cefe4e313076065f3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Takeshi Harayama\nTitle: \nConnecting lipid tail structure
 s to cellular functions\n\nAbstract: \nCellular membranes are composed of 
 a diverse set of lipids with tails that vary significantly in chain length
 s\, the number of double bonds and the positions of these double bonds. Al
 though lipids with uniform tails are sufficient to make bilayers in vitro\
 , the diversity in lipid tail structures is seen across the tree of life\,
  suggesting the biological importance of having lipids with distinct tails
 . It is critical to decode the functional relevance of lipid tails to unde
 rstand the basic architecture of our cells\, and to correctly assess the i
 mportance of lipidome changes that are seen in various diseases. For this\
 , we are developing tools that combine genetics and synthetic lipid feedin
 g to manipulate the tail composition of membrane lipids in cells\, allowin
 g us to study their consequences. In this seminar\, I will discuss how an 
 optimal combination of lipid head groups and tails is generated in cells\,
  and how they contribute to cellular processes\, such as ferroptosis\, whi
 ch is a lipid peroxidation-dependent cell death.\n\nSpeaker: \n2020-now 
        Group Leader\, Institut de Pharmacologie Moléculaire et Cell
 ulaire\, Université Côte d’Azur - CNRS - Inserm\, France\n2015-2020 
       Postdoctoral researcher\, Biochemistry department\, University 
 of Geneva\, Switzerland (Howard Riezman lab)\n2011-2015       Postdo
 ctoral researcher\, University of Tokyo and National Center for Global Hea
 lth and Medicine\, Japan (Takao Shimizu lab)\n2011            
     Ph.D. (Graduate School of Medicine\, The University of Tokyo\, Japa
 n\, Takao Shimizu lab)
LOCATION:MA A1 10 https://plan.epfl.ch/?room==MA%20A1%2010
STATUS:CONFIRMED
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