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SUMMARY:Life Sciences Seminar Series: Gaudenz Danuser - Imaging the cell m
 orphological control of oncogenic signals
DTSTART:20241108T153000
DTEND:20241108T163000
DTSTAMP:20260506T114638Z
UID:9796037a26d6df461e43ed1d5781b60e7e10ff1da49ded22f55d3c55
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gaudenz Danuser\nWe’re excited to relaunch the Life Sciences
  Seminar Series (LSS)! These seminars showcase cutting-edge research acros
 s the diverse fields of life sciences. We’re kicking off the series with
  a fascinating talk by Gaudenz Danuser\, who joins us from University of T
 exas Southwestern Medical Center (UTSW).\n\nWe hope you’ll join us for t
 his exciting first event\, and stay for the apero to connect with fellow r
 esearchers.\n\nAbstract\nCell morphology is used in research and clinical 
 practice as a signature of cell behavior. Many studies have linked cell mo
 rphotype to function\, and for almost two centuries pathologists have expl
 oited morphology as biomarkers for the diagnosis and stratification of dis
 ease. The tight association between a cell morphotype and a cell state has
  gained even more significance with the growing number of machine learning
  applications that derive from morphology predictions not only of behavior
  but of genetic and molecular cell states. Regardless of whether the conne
 ction between morphology and cell state is analyzed by human or machine\, 
 these analyses place the morphotype implicitly or explicitly downstream of
  cell state regulation\, i.e.\, ‘form follows function’. However\, our
  recent work has provided evidence that cell morphology is part of the reg
 ulator\, i.e.\, ‘function follows form’. We have identified mechanisms
  by which cell shape dictates signaling and metabolism. Especially in the 
 context of cancer we find that specific morphogenic programs amplify the o
 ncogenic penetrance of genetic and molecular aberrations and/or confer ada
 ptive drug resistance. These discoveries have been enabled by innovation i
 n microscopy and computer vision to quantify with high resolution the inte
 rplay between signaling and morphogenesis in experimental systems that do 
 not artificially constrain morphogenesis. \n\nBio\nGaudenz Danuser is the
  founding chair of the Lyda Hill Department of Bioinformatics at the Unive
 rsity of Texas Southwestern Medical Center (UTSW). He is also the Director
  the Cecil H. and Ida Green Center for Systems Biology\, he holds the Patr
 ick E. Haggerty Distinguished Chair in Basic Biomedical Science and is a S
 cholar of the Cancer Prevention and Research Institute of Texas (CPRIT). B
 efore moving to UTSW\, Danuser led research laboratories at ETH Zurich\, a
 t The Scripps Research Institute\, and at Harvard Medical School.\nHis lab
 ’s research is currently focused on understanding the roles shape regula
 tion play in metastatic cell proliferation\, survival and therapy resistan
 ce. To address these questions the lab develops innovative quantitative im
 aging methods to experimentally probe these processes and uses machine lea
 rning and tools from financial mathematics to compile the data in mechanis
 tic models. He is a devoted teacher in areas of computational cell biology
  and AI both at the institutional and international level.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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