BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Breaking resistance of pathogenic bacteria by chemical strategies
DTSTART:20241029T161500
DTEND:20241029T171500
DTSTAMP:20260506T133055Z
UID:6b3c8ff50e0ef3930df2c46083f06fb57905ef1af4824dc067895eb4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dr. Stephan Sieber\nMultiresistant bacterial pathogens s
 uch as Methicillin-resistant Staphylococcus aureus (MRSA) are responsible 
 for a variety of severe infections that pose a significant threat to globa
 l health. To approach this challenge new chemical entities with an unprece
 dented mode of action are desperately needed. This presentation will cover
  our latest efforts to identify new anti-bacterial targets and correspondi
 ng chemical inhibitors. A proteome mining approach will be presented to id
 entify novel antibiotic targets. Small molecule cofactor mimics infiltrate
  the bacterial metabolic machinery leading to their incorporation in cofac
 tor-dependent enzymes. Their analysis via mass-spectrometry revealed the f
 unction of uncharacterized proteins in important bacterial pathways as wel
 l as the identification of novel antibiotic hits along with their mode of 
 action. In addition\, we identified new synthetic or natural product deriv
 ed compound classes that effectively kill pathogenic bacteria. Chemical sy
 nthesis of improved derivatives led to the identification of active molecu
 les with nanomolar potency and suitable metabolic stability. The mode of a
 ction was investigated by diverse methodologies including affinity based p
 rotein profiling (AfBPP). For example\, one compound stimulates a signal p
 eptidase correlating with enhanced secretion of extracellular proteins. Th
 ese included essential cell-wall remodeling enzymes whose dysregulation li
 kely explains the associated antibiotic effects
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR