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SUMMARY:EPFL BioE Talks SERIES  "Exploring and Exploiting the Secretory Pa
 thway in Mammalian Cells"
DTSTART:20241104T121500
DTEND:20241104T131500
DTSTAMP:20260410T152242Z
UID:30cf2fc97d73e89b3199714a9ed0af4cbf73b9a6e5aee210db056232
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Franck Perez\, Institut Curie\, Paris (FR)\nWEEKLY EPFL 
 BIOE TALKS SERIES (sandwiches provided)\n\nAbstract:\nTo regulate their ho
 meostasis – to exchange signals with the extracellular environment or mi
 grate for example – cells need to address particular proteins and lipids
  toward specific compartments in a tightly controlled way. Golgi-dependent
  trafficking plays an essential role in these processes but although our k
 nowledge about the mechanisms of intra-Golgi transport and sorting has dra
 matically increased over the past two decades\, the underlying complexity 
 of transport routes\, in term of mechanism and dynamics\, is only starting
  to emerge.\n\nOver the years\, we developed several versatile assays to m
 onitor and quantify transport of cargos to the cell surface like the RUSH 
 assay and the CATCHFIRE system that brings powerful ways to study and pert
 urb cell dynamics in real-time. Recently\, we applied these set of tools t
 o understand better how the cell surface PD-L1 is translocated in the secr
 etory pathway and transported to the cell surface. We also exploited our t
 rafficking assays to develop novel translational approaches\, screen for i
 nhibitory molecules and and set-up tunable cell-based therapies.\n\n\nBio:
 \nFranck Perez is Research Director at CNRS and Chairman of the "Cell Biol
 ogy and Cancer" Unit of the Institut Curie in Paris. His group is studying
  intracellular trafficking with an important focus on the development of n
 ew methods and tools for Cell Biology studies. For example\, he developed 
 at the Institut Curie the use of automated cellular screening and co-found
 ed a High Content screening platform (BioPhenics\, directed by Elaine del 
 Nery). In addition\, his group created a novel trafficking assay and have 
 strongly invested on the development of recombinant antibodies for cell bi
 ology. Notably\, with Sandrine Moutel he developed a novel antibody librar
 y based on a humanized nanobody scaffold and created a therapeutic antibod
 y platform to exploit and share these technologies.\n\nPrior to being recr
 uited by CNRS\, F. Perez was Maître-Assistant at the University of Geneva
  in Switzerland\, in the laboratory of Prof. T. E Kreis (1996-1999) where 
 he worked on microtubule dynamics and intracellular trafficking. F. Perez 
 received his PhD. in 1996 for his work in the laboratory of A. Prochiantz 
 at the Ecole Normale Supérieure (Paris\, France) on the regulation of neu
 roendocrine secretion and on the development of cell internalization pepti
 des. Before his PhD.\, F. Perez graduated in Cell biology and Genetics at 
 the University Paris VII.\n\nF. Perez is an EMBO member\, author of hundre
 d and fifty articles and over twelve patents. He is the co-founder of four
  biotech companies (Emglev therapeutics (now Valour Bio)\, Honing Bioscien
 ces\, The Twinkle Factory and Mnemo therapeutics).\n\n\nZoom link (with on
 e-time registration for the whole series) for attending remotely: https://
 go.epfl.ch/EPFLBioETalks\n\n\nInstructions for 1st-year Ph.D. students who
  are under EDBB’s mandatory seminar attendance rule:\nIN CASE you cannot
  attend in-person in the room\, please make sure to\n\n	send D. Reinhard a
  note well ahead of time (ideally before seminar day)\, informing that you
  plan to attend the talk online\, and\, during seminar:\n	be signed in on 
 Zoom with a recognizable user name (not any alias making it difficult or i
 mpossible to identify you).\n\nStudents attending the seminar in-person sh
 ould collect a confirmation signature after the talk - please print your o
 wn signature sheet beforehand (71 kB pdf available for download here). IMP
 ORTANTLY: hang on to this sheet as no signature record is being kept by an
 yone else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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