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SUMMARY:Ardem Patapoutian | May the Force be with you!  Piezo channels in 
 mechanosensory biology.
DTSTART:20250127T141500
DTEND:20250127T151500
DTSTAMP:20260507T040227Z
UID:cba586ffd13496c1fd1265d22b6b124ee226dab0f988828f5d3a797f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ardem Patapoutian\, Scripps Research\, California\, USA\nMay t
 he Force be with you!  Piezo channels in mechanosensory biology.\n\nArdem
  Patapoutian\, Nobel Laureate in Physiology or Medicine (2021)\, Professor
  at Scripps Research\, Investigator\, Howard Hughes Medical Institute\; Pr
 esidential Endowed Chair in Neurobiology.\n\nAbstract\nMechanotransduction
  was perhaps the last major sensory modality not understood at the molecul
 ar level. Proteins/ion channels that sense mechanical force are postulated
  to play critical roles in sensing touch/pain (somatosensation)\, sound (h
 earing)\, shear stress (cardiovascular function)\, etc.\; however\, the id
 entity of ion channels involved in sensing mechanical force had remained e
 lusive. The Patapoutian lab identified PIEZO1 and PIEZO2\, mechanically ac
 tivated cation channels that are expressed in many mechanosensitive cell t
 ypes. Genetic studies established that PIEZO2 is the principal mechanical 
 transducer for touch\, proprioception\, baroreception\, bladder\, and lung
  stretch\, and that PIEZO1 mediates blood-flow sensing\, which impacts vas
 cular development and iron homeostasis. Clinical investigations have confi
 rmed the importance of these channels in human physiology. Current work in
  Patapoutian lab continues to explore the role of mechanosensation and int
 eroception in physiology and disease.\n\nThis event is part of the Life Sc
 iences Seminar Series and the BMI Distinguished Seminar Series\, hosted by
  the Mackenzie Mathis Lab. The seminar is followed by a coffee break for f
 ellow researchers to connect.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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