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SUMMARY:ChemBio Seminar by Prof. Arnaud Gautier (Sorbonne Université\, Fr
 ance)
DTSTART:20250415T160000
DTEND:20250415T170000
DTSTAMP:20260429T152746Z
UID:c8ab42ef4e677a7ee078453c2e0ba35eec3eba0db20b1a532dada33c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Title: Controlling cell function through fluorogenic chemicall
 y induced dimerization\n\nSpeaker: Arnaud Gautier is Professor of Chemistr
 y at Sorbonne University in Paris (France) and head of the team Chemogenet
 ics for observing and controlling cell functions\, co-affiliated to the re
 search unit ‘Chimie Physique et Chimie du Vivant’ (affiliated to Sorbo
 nne University\, École Normale Supérieure and CNRS) and the research uni
 t ‘Chemical Biology of Cancer’ (affiliated to Institut Curie\, INSERM 
 and CNRS). He studied chemistry at the Ecole Normale Supérieure de Lyon\,
  where he received a PhD in chemistry in 2005. In 2006\, he joined the gro
 up of Kai Johnsson at the École Polytechnique Fédérale of Lausanne wher
 e he developed methods for labeling proteins in living cells. In 2009\, he
  joined the group of Jason W. Chin at the MRC laboratory of Molecular Biol
 ogy in Cambridge\, where he worked on the expansion of the genetic code of
  mammalian cells. Arnaud Gautier was Assistant Professor at the Ecole Norm
 ale Supérieure from 2010 to 2019\, before joining Sorbonne University in 
 2019 as Full Professor. Arnaud Gautier’s lab has pioneered the developme
 nt of chemogenetic tools that enable the observation and control of biomol
 ecules and dynamic biochemical events within living cells and tissues. By 
 combining chemistry with cutting-edge genetic techniques\, these tools can
  allow biologists to investigate fundamental mechanisms\, explore the caus
 es of diseases\, and develop novel therapeutic strategies\n\nAbstract: Cel
 lular activities are orchestrated by the precise spatial and temporal orga
 nization of proteins. This involves compartmentalizing proteins within org
 anelles or at the plasma membrane\, as well as assembling them into comple
 xes through scaffold proteins. Technologies that enable to chemically cont
 rol protein interaction/proximity have been invaluable for understanding h
 ow the spatiotemporal protein organization influence processes like gene e
 xpression\, protein trafficking\, signalling\, metabolism\, immunity and c
 ell–cell communication. In this presentation\, I will introduce CATCHFIR
 E (chemically assisted tethering of chimera by fluorogenic induced recogni
 tion)\, a self-reporting chemically induced dimerization technology enabli
 ng to control protein proximity and thus cellular processes with high temp
 oral control. CATCHFIRE employs genetically fused dimerizing domains that 
 interact in the presence of fluorogenic inducers of proximity\, which beco
 me fluorescent upon complex formation. This self-reporting ability enables
  real-time tracking of chemically induced protein proximity. I will presen
 t how CATCHFIRE can be applied to rapidly and reversibly control protein l
 ocalization\, trafficking\, organelle transport\, and cellular processes\,
  opening new avenues for studying and manipulating biological functions wi
 th high spatiotemporal precision.
LOCATION:SG 1138 https://plan.epfl.ch/?room==SG%201138
STATUS:CONFIRMED
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