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SUMMARY:ChemBio Seminar by Prof. Jeremy Baskin (Cornell University\, USA)
DTSTART:20250408T160000
DTEND:20250408T170000
DTSTAMP:20260314T205207Z
UID:73de2b43d2e1fc7eebeada7d941650810fb7b78570ce96b9bbfff16c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Title: Imaging\, Editing\, and Deciphering the Lipidome\n\nSpe
 aker: Jeremy M. Baskin is Associate Professor\, Nancy and Peter Meinig Fam
 ily Investigator in the Life Sciences\, and Director of the Chemistry–Bi
 ology Interface Program at Cornell University\, with appointments in the D
 epartment of Chemistry and Chemical Biology and the Weill Institute for Ce
 ll and Molecular Biology. He was born and raised in Montreal\, Canada and 
 received his undergraduate education at the Massachusetts Institute of Tec
 hnology\, with a major in Chemistry and minors in Biology and Music. Jerem
 y carried out Ph.D. studies supported by NDSEG and NSF graduate fellowship
 s in Carolyn Bertozzi’s group at the University of California\, Berkeley
 \, focusing on development of bioorthogonal chemistries. Jeremy received p
 ostdoctoral training in cell biology as a Jane Coffin Childs fellow at Yal
 e University with Pietro De Camilli. Research in the Baskin lab centers on
  the chemical biology and cell biology of lipid signaling\, with a focus b
 oth on development of tools for imaging and editing cellular lipids and el
 ucidation of mechanisms underlying physiological and pathological lipid me
 tabolism and signaling events. Jeremy has been the recipient of numerous a
 wards\, including Beckman Young Investigator\, Sloan Research Fellowship\,
  NSF CAREER\, ACS Young Academic Investigator\, ASBMB Walter A. Shaw Young
  Investigator in Lipid Research\, and ICBS Young Chemical Biologist Award.
 \n\nAbstract: Phospholipids are the major constituents of cellular membran
 es and also important signaling molecules. Because these hydrophobic metab
 olites are not directly genetically encoded\, their detection and precise 
 manipulation with traditional genetic methods is challenging. Therefore\, 
 chemical methods for detecting the biosynthesis and intracellular transpor
 t of lipids\, as well as those for modulating their levels with a high deg
 ree of spatiotemporal control\, are urgently needed. I will highlight our 
 latest advances in applying bioorthogonal chemistry\, activity-based imagi
 ng\, protein engineering\, directed evolution\, and optogenetics toward th
 e development of small molecule-based tools for visualizing phospholipid b
 iosynthesis and interorganelle transport. As well\, I will describe light-
 controlled enzymes that we term membrane editors for precise manipulation 
 of the lipid composition of target organelle membranes in live cells\, wit
 h a focus throughout on strategies for tool development and biological app
 lications to reveal insights into regulation of lipid metabolism\, transpo
 rt\, signaling\, and interactions with the proteome.
LOCATION:ME B3 31 https://plan.epfl.ch/?room==ME%20B3%2031
STATUS:CONFIRMED
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