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SUMMARY:ChemBio Seminar by Prof. Saranna Fanning (Harvard Medical School a
 nd Brigham & Women’s Hospital\, USA)
DTSTART:20250328T160000
DTEND:20250328T170000
DTSTAMP:20260429T115210Z
UID:d386db4cafd937e376aac2e09df9f5d9a246cc3cb429940e465db38d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Title: Lipid Dyshomeostasis Pinpoints Therapeutic Target Strat
 egies for Parkinson’s Disease and Synucleinopathies.\n\nSpeaker: Saranna
  Fanning is an Assistant Professor in Neurology at Harvard Medical School 
 and Brigham & Women’s Hospital. Dr. Fanning received her BSc and PhD deg
 rees in Microbiology from University College Cork (UCC)\, performing her d
 octoral research in the labs of Dr. Douwe Van Sinderen (UCC) and Dr. Aaron
  Mitchell (Columbia University\, NY\, Carnegie Mellon University\, PA). Sh
 e performed her postdoctoral training in the lab of Dr. Susan Lindquist at
  the Whitehead Institute for Biomedical Research\, MIT\, MA and Dr. Dennis
  Selkoe’s Lab at Harvard Medical School and Brigham & Women’s hospital
 . As an Assistant Professor\, her lab investigates the role of lipid metab
 olism in neurodegenerative diseases. She is particularly focused on identi
 fying therapeutic targets for Parkinson’s disease\, one of which has ent
 ered clinical trials.\n\nAbstract: Establishing mechanism-based therapeuti
 cs for synucleinopathies including Parkinson’s disease and Lewy body dem
 entia is a biomedical priority. Genetic and neuropathological discoveries 
 implicate α-synuclein (αS) in these diseases. Hence\, these diseases hav
 e traditionally been considered proteinopathies. Data now strongly support
  an αS/lipid interplay and a major role for lipids in modulating α-synuc
 leinopathy phenotypes in the brain. Our goal is to apply a new proteinopat
 hy+lipidopathy paradigm to identify new therapeutic targets and strategies
  premised on correcting the αS dysregulated lipidome.
LOCATION:CE 1 1 https://plan.epfl.ch/?room==CE%201%201
STATUS:CONFIRMED
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