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SUMMARY:Bill & Melinda Gates Foundation - Global Grand Challenges: Innovat
 ions for Gram-Negative Antibiotic Discovery
DTSTART;VALUE=DATE:20250325
DTSTAMP:20260313T145015Z
UID:ca33f7ed6179ee9939f0e37ae08a5367d0664b321ed7bd3137c32d23
CATEGORIES:Conferences - Seminars
DESCRIPTION:Aim:  The ultimate objective of Gr-ADI will be to enable disc
 overy of safe and simple first-line broad-spectrum drugs for syndromic man
 agement\, through:\n\n	Development of novel and emerging biological\, chem
 ical\, and AI tools that could be applied broadly for antibiotic discovery
  to identify new antibiotic targets.\n	Application of these innovative app
 roaches to generate chemical starting points for project-based drug discov
 ery.\n	Fostering a collective mindset to address gaps in knowledge\, solve
  problems\, and manage a portfolio of targets and hits\n\nThis Grand Chall
 enges RFP will identify and select the first projects within the consortiu
 m. The focus of this RFP will be on the discovery of antibiotics with bro
 ad spectrum activity against Enterobacteriaceae\, using Klebsiella spp.
  as the pathogen to initiate a discovery program. This provides a common f
 ocus point on Klebsiella spp. for all projects in the consortium and fac
 ilitates sharing of knowledge and data for mutual benefit. As such\, propo
 sals must have a primary focus on Klebsiella spp. but can also include i
 nvestigation of other Enterobacteriaceae.\n\nProposals must address at le
 ast one of the following themes:\n\n\n	Development of genome-scale tools o
 r other innovative technologies to identify new chemical starting points l
 inked to targets as well as assessment of potential drug target vulnerabil
 ity\, singly or in combination.\n	Development of innovative technologies t
 o select targets and chemical leads with a very high bar to resistance.\n	
 Gaining a better understanding of the chemistry underlying penetration of 
 compounds to different compartments of the bacterial cell to build a platf
 orm to rapidly test whether compounds reach and accumulate at their target
 .\n	Development of novel and coordinated approaches to identifying new che
 mical leads for clinically or in vivo validated drug targets\, for which
  there is currently no agent in Phase 3.\n\nThe funded projects will colle
 ctively form a consortium to catalyze and accelerate early antibiotic drug
  discovery. The funded organizations (including collaborators receiving Gr
 -ADI funding) will be required to enter into a consortium-wide data sharin
 g agreement (before they receive their funding) to facilitate their intera
 ctions and to maximize cross-learnings and integration. Applicants should 
 review and consider the Gr-ADI Cooperation and Data Sharing Principles\, 
 which will be reflected in the formal data sharing agreement. The full dat
 a sharing agreement will be shared with applicants invited to submit a ful
 l application.\n\nThis Grand Challenge is a collaboration between the Gate
 s Foundations\, Nova Nordisk Foundation and Wellcome\, but each funder wil
 l make independent funding decisions. Applicants successful at the prelimi
 nary stage will be invited to submit a full application via GF\, NNF\, or 
 Wellcome as applicable. Before applying\, applicants should familiarize th
 emselves with the supporting documents for this Grand Challenge\, includin
 g the terms and conditions of Wellcome\, the Gates Foundation\, and the
  Novo Nordisk Foundation\, Rules and Guidelines\, Application Instructi
 ons\, and Frequently Asked Questions. \n\nFunding: max. $5\,000\,000 (in
 cl. 15% overheads)\n\nDuration: max. 3 years\n\nEligibility: This initiati
 ve is open to nonprofit organizations\, for-profit companies\, internation
 al organizations\, government agencies\, and academic institutions. Applic
 ations from institutions based in LMICs and projects led by women and othe
 r groups that are historically under-represented in the drug discovery fie
 ld are encouraged. All applications received will then be reviewed on thei
 r merits.\n\nHow to Apply: Applicants should apply through the application
  portal. The letter of inquiry\, with a scientific proposal should not to 
 exceed five pages. The budget table and narrative can be found here. Budg
 ets should include 15% indirect costs (max. allowed amongst potential fund
 ers). Upon registration\, applicants must provide information about the ta
 x status of their organization\; please contact the Research Office for as
 sistance.\n\nDeadline: 25 March 2025 – 11:30 am PT\n\nFurther informatio
 n\n\n\n	More information about the program is available here\n	The applica
 tion portal can be found here\n	For any other questions\, please contact t
 he Research Office\n
LOCATION:
STATUS:CONFIRMED
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