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SUMMARY:MechE Colloquium: Engineering Robust Genetic Control Systems: Theo
 ry and Implementation
DTSTART:20250304T120000
DTEND:20250304T130000
DTSTAMP:20260525T080613Z
UID:dd30e867062e87c105852a1e988a08b025fed3de48ee5fe2d99f7739
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Mustafa Khammash\, Department of Biosystems Science and
  Engineering\, ETH Zurich\nAbstract: Feedback regulation is a fundamenta
 l principle in biology\, providing essential mechanisms for organisms to a
 dapt and thrive in ever-changing environments. In this talk\, I will pres
 ent the theoretical framework and key concepts essential for designing gen
 etic control systems capable of achieving robust perfect adaptation (RPA)\
 , a biological process that ensures a specific variable remains at a desir
 ed setpoint despite continuous perturbations in the underlying network. F
 rom a theory perspective\, I will elucidate how RPA imposes critical struc
 tural constraints on the underlying networks that can be characterized by 
 simple linear algebraic conditions. These conditions in turn impose an int
 egral feedback structure on RPA achieving networks\, a fact that yields in
 sight into how RPA mechanisms can be realized with biomolecular reactions.
  Building on these insights\, I will introduce a novel internal model prin
 ciple (IMP) tailored for biomolecular networks\, akin to celebrated IMP in
  control theory. Finally\, I will relate these theoretical developments to
  practical implementation of RPA-achieving controllers and their applicati
 ons. I will demonstrate the implementation of genetically engineered synth
 etic RPA controllers in different cell types and showcase their tunability
  and adaptation properties.\n\n\nBiography: Professor Mustafa Khammash wo
 rks in the field of Control Theory and Systems and Synthetic Biology. He i
 s currently a professor at the Department of Biosystems Science and Engine
 ering (D-BSSE) at ETH Zurich. Prof. Khammash received his Ph.D. from Rice
  University in 1990 in Electrical Engineering. After completing his Ph.D.\
 , he joined the Electrical Engineering Department at Iowa State University
 \, where he established the Dynamics and Control Program. In 2001\, he bec
 ame a member of the Mechanical Engineering faculty at the University of Ca
 lifornia\, Santa Barbara (UCSB). During his tenure at UCSB\, he served as 
 the Director of the Center for Control\, Dynamical Systems\, and Computati
 on. In 2011\, Prof. Khammash moved to Switzerland\, joining ETH Zurich. He
  has held various positions there\, including serving as the head of the D
 epartment of Biosystems Science and Engineering. His research at ETH Zuri
 ch involves working at the interface of systems biology\, synthetic biolog
 y\, and control theory. His work is pivotal in the development of Cybergen
 etics in synthetic biology\, focusing on the real-time control of the dyna
 mic behavior of living cells with applications in various areas such as in
 dustrial biotechnology\, tissue engineering\, and medical therapy. His lab
 oratory at ETH Zurich combines expertise from various disciplines\, includ
 ing engineering\, mathematics\, computational science\, physics\, and biol
 ogy\, to advance the theoretical and experimental foundations of Cybergene
 tics. Prof. Khammash is a Fellow of the IEEE\, IFAC\, the Japan Society f
 or the Promotion of Science\, and the Asia-Pacific Artificial Intelligence
  Association. He is the winner of the prestigious European Research Counci
 l Advance grant (2018) and the Swiss National Science Foundation Advanced 
 grant (2023).
LOCATION:MED 0 1418 https://plan.epfl.ch/?room==MED%200%201418 https://epf
 l.zoom.us/j/64267570786
STATUS:CONFIRMED
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