BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:EPFL BioE Talks SERIES "Slow Cell Migration and Fluctuations Can Help Eradicate Cooperative Antimicrobial Resistance in Time-Varying Enviro nments" DTSTART:20250407T123000 DTEND:20250407T133000 DTSTAMP:20260509T215444Z UID:5306ad4a4e68d3108b1cf61dae1b4cc319f29c76cb64311abb849171 CATEGORIES:Conferences - Seminars DESCRIPTION:Prof. Mauro Mobilia\, School of Mathematics\, University of Le eds (UK)\nWEEKLY EPFL BIOE TALKS SERIES (sandwiches provided)\n\nMIND THE TIME CHANGE: TALK AT 12:30 INSTEAD OF 12:15!\n\nAbstract:\nAntimicrobial r esistance (AMR) is a global threat and combating its spread is of paramoun t importance. AMR often results from a cooperative behaviour with shared d rug protection [1]. Microbial communities generally evolve in volatile\, s patially structured settings. Migration\, fluctuations\, and environmental variability thus significantly impact AMR. While AMR is enhanced by cell migration in static conditions\, this changes in time-fluctuating spatiall y structured environments [2]. In this talk\, we will consider a two-dimen sional metapopulation consisting of demes in which drug-resistant and sens itive cells evolve in a time-changing environment containing a toxin again st which protection can be shared. Cells migrate between demes and connect them. When the environment varies neither too quickly nor too slowly\, po pulation bottlenecks cause extinctions countered by migration. In discussi ng the influence of migration and environmental variability on AMR\, we wi ll unveil the near-optimal conditions for resistance eradication and show how slow migration speeds up and enhances AMR clearance. Time permitting\, I will outline the potential impact of our studies on laboratory-controll ed experiments. Research funded by the EPSRC and NSF.\n\nReferences:\n[1] L. Hernandez-Navarro\, M. Asker\, A. M. Rucklidge\, and M. Mobilia. J. R. Soc. Interface\, 20\, 20230393 (2023). https://royalsocietypublishing.org/ doi/10.1098/rsif.2023.0393\n[2] L. Hernandez-Navarro\, K. Distefano\, U. C . Tauber\, and M. Mobilia. BioRxiv 2024.12.30.630406. https://doi.org/10.1 101/2024.12.30.630406\n\nBio:\nMauro Mobilia obtained his PhD from EPFL in 2002 with a thesis on non-equilibrium statistical physics. From 2002 to 2 005\, he was a postdoctoral fellow at Boston University and Virginia Tech on a fellowship from the Swiss National Science Foundation (SNSF). In 2005 \, he was awarded a Humboldt Research Fellowship that he held at the Ludwi g Maximilian University of Munich. He then worked as a Research Fellow in Mathematics and at the Centre for Complexity Science of the University of Warwick (2007-2009) on an advanced SNSF fellowship. Since 2009\, he has be en at the School of Mathematics of the University of Leeds where he is a f ull professor (chair) of Applied Mathematics. His research is at the inter face of mathematical biology\, population dynamics and statistical physics . He is currently the principal investigator of the project "Eco-Evolution ary Dynamics of Fluctuating Populations" funded by the EPSRC and NSF in th e UK and USA. At Leeds\, Mauro teaches evolutionary modelling and mathemat ical biology.\n\n\nZoom link (with one-time registration for the whole ser ies) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstruc tions for 1st-year Ph.D. students planning to attend this talk\, who are u nder EDBB’s mandatory seminar attendance rule:\nIN CASE you cannot atten d in-person in the room\, please make sure to\n\n send D. Reinhard a note well ahead of time (ideally before seminar day)\, informing that you plan to attend the talk online\, and\, during seminar:\n be signed in on Zoom w ith a recognizable user name (not any alias making it difficult or impossi ble to identify you).\n\nStudents attending the seminar in-person should c ollect a confirmation signature after the talk - please print your own sig nature sheet beforehand (69 kB pdf available for download here). IMPORTANT LY: hang on to this sheet as no signature record is being kept by anyone e lse! LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/ EPFLBioETalks STATUS:CONFIRMED END:VEVENT END:VCALENDAR