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SUMMARY:ChemBio Seminar by Prof. Nora Kory - Harvard T.H. Chan School of P
 ublic Health - CH637
DTSTART:20250523T161500
DTEND:20250523T171500
DTSTAMP:20260317T104537Z
UID:4dac317adff7d95745fa2ec7c0ca01ba51193a39d672b849ea2a066e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Nora Kory\nTitle: \nMitochondrial transporters and the c
 ontrol of cellular metabolism\n\nAbstract:\nHumans encounter over 200\,000
  metabolites through diet and modern living. Intricate mechanisms of cellu
 lar compartmentalization enable organisms to orchestrate such metabolic co
 mplexity. We explore how organelles control key metabolite concentrations 
 and establish dynamic cellular environments\, with a focus on solute carri
 ers and other transport proteins.\nOne major research direction in our lab
  aims to define the functions of compartmentalization in metabolic regulat
 ion\, particularly concerning nicotinamide adenine dinucleotide (NAD). Dec
 reased NAD levels with aging are linked to mitochondrial dysfunction and o
 ther aging-related changes. Our recent identification of SLC25A51 as a mit
 ochondrial NAD transporter gives us a tool to understand how intracellular
  NAD compartmentalization affects key cellular processes and physiological
  outcomes. Notably\, we have identified the mitochondrial NAD transporter 
 SLC25A51 as a modulator of cellular senescence in pancreatic beta cells. W
 e demonstrate that deleting the transporter prevents diabetes-associated b
 eta cell senescence and improves glucose homeostasis and insulin resistanc
 e in mice.\n\nBiography:\nDr. Nora Kory completed her undergraduate and ma
 ster’s studies in chemistry and biochemistry at Munich University before
  moving to the United States. At Yale University\, she combined her passio
 ns for metabolism and cell biology to study the molecular mechanisms of ho
 w cells store fat. Her PhD research identified factors that determine the 
 lipid droplet protein composition. During her postdoctoral studies at the 
 Whitehead Institute for Biomedical Research\, Dr. Kory discovered elusive 
 transport proteins responsible for bringing critical metabolites into mito
 chondria. Her current research focuses on how mitochondria exchange metabo
 lites with the rest of the cell while maintaining their unique chemical en
 vironment. Motivated by the consequences of mitochondrial dysfunction on n
 umerous diseases\, Dr. Kory’s overarching goals are to understand how al
 terations in mitochondrial transport influence aging and age-related disea
 ses and to leverage this knowledge for therapeutic development. Her ground
 breaking contributions have earned her a K99/R00 Pathway to Independence A
 ward from the National Cancer Institute\, a R35 Maximizing Investigators' 
 Research Award from the National Institutes of General Medical Sciences\, 
 a Damon Runyon-Rachleff Innovation Award\, and recognition as a STAT Wunde
 rkind.\n\nWebsite:\nkory-lab.com
LOCATION:CE 1 5 https://plan.epfl.ch/?room==CE%201%205
STATUS:CONFIRMED
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