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SUMMARY:BMI Seminar // Randy Bruno: High-order thalamus in behavior
DTSTART:20250516T090000
DTEND:20250516T100000
DTSTAMP:20260417T012138Z
UID:97a946bccfdfc2229496f0790eeb91c44cae6ec5029e171519b3c419
CATEGORIES:Conferences - Seminars
DESCRIPTION:Randy Bruno\, University of Oxford\, UK\nEach sensory modalit
 y has its own primary and secondary (“high-order”) thalamic nuclei. Wh
 ile the primary thalamic nuclei are well understood to relay sensory infor
 mation from the periphery to the cortex\, the role of high-order sensory n
 uclei is elusive. One theory has been that these collect reafferent motor 
 signals and/or motor efference copy to disambiguate movements from environ
 mental stimuli\, but our results demonstrate poor encoding of motor inform
 ation. Another theory has been that secondary nuclei may support feature-b
 ased attention. If true\, one would also expect the activity in different 
 nuclei to reflect the degree to which modalities are or are not behavioral
 ly relevant in a task. We trained head-fixed mice to attend to one sensory
  modality while ignoring a second modality and simultaneously recorded fro
 m secondary somatosensory and visual thalamus. Training could switch the m
 odality that maximally activated a secondary thalamic nucleus. Secondary n
 uclei appear to encode behaviorally relevant\, reward-predicting stimuli r
 egardless of stimulus modality. This does not produce multimodal encoding 
 in sensory cortex\, but may instead gate plasticity of apical dendrites in
  cortical layer 1 to enable them to acquire the behaviorally relevant task
  dimension.
LOCATION:SV 2510 https://plan.epfl.ch/?room==SV%202510
STATUS:CANCELLED
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