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SUMMARY:BMI Seminar // Varun Sreenivasan: Establishing E/I ratios through 
 programmed cell death - Mechanisms and circuit function
DTSTART:20250509T090000
DTEND:20250509T100000
DTSTAMP:20260416T113424Z
UID:fe8e95ae9f5472193481d9d1e09f30449d24792faf5194ffb137c459
CATEGORIES:Conferences - Seminars
DESCRIPTION:Varun Sreenivasan\, University of Sussex\, UK\nProper balance
  between excitation and inhibition (E/I balance) is critical for brain fun
 ction. However\, the underlying mechanisms that establish this balance re
 main poorly understood. Here\, I will present evidence from the neocortex 
 and the striatum which point to activity dependent input-specific mechani
 sms that rescue GABAergic interneurons from programmed cell death during 
 early postnatal development. I will show that genetically altering cellula
 r E/I ratios by preventing cell death can impact the encoding of sensory 
 signals within cortical circuits in a task-dependent manner. Finally\, I w
 ill briefly discuss the implications of these findings in the context of 
 neurodevelopmental disorders.\n 
LOCATION:SV 2510 https://plan.epfl.ch/?room==SV%202510
STATUS:CONFIRMED
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