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SUMMARY:BMI Seminar // Tanya Sippy: Modulation of striatal neuron membrane
  potential dynamics by movement
DTSTART:20250509T160000
DTEND:20250509T170000
DTSTAMP:20260430T150417Z
UID:ff8e049533dc60aad1503cfa2673301dcbe935ae246e0e5b1273edd3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Tanya Sippy\, New York University\, US\nAs the input nucleus o
 f the basal ganglia\, the striatum has been heavily implicated in the gene
 ration and selection of motor commands. Despite this\, we know very little
  about how different types of movement activate D1 and D2 striatal project
 ion neurons (SPNs) that make up the direct and indirect pathways of this s
 tructure. To investigate this\, we conducted in vivo whole-cell membrane p
 otential (Vm) recordings from D1 and D2 SPNs in the striatum of head-fixed
  mice in three behavioral paradigms – (1) under anesthesia\, (2) awake o
 n a stationary platform\, and (3) awake on a mobile disk. Under anesthesia
 \, Vm is bimodal\, exhibiting slow-wave fluctuations at 1 – 4 Hz. Howeve
 r\, bimodality is progressively attenuated in awake motor states\, with la
 rgely unimodal Vm dynamics present in animals on a mobile disk. We then ch
 aracterized how different types of movement activate D1- and D2 SPNs. We f
 ound that\, for animals on the stationary platform\, orofacial movements s
 uch as whisking and grooming evoke larger and faster depolarizations in D1
 -SPNs compared to D2-SPNs. In contrast\, in animals on the mobile disk\, D
 1 and D2 SPNs showed similar depolarizations at movement onset. Finally\, 
 we found that chronic dopamine depletion abolished cell type specific recr
 uitment during facial movements. Our work finds evidence for both biased a
 nd parallel activation of direct and indirect pathways depending on moveme
 nt type\, with biased activation requiring intact dopamine signaling.\n 
LOCATION:SV 2510 https://plan.epfl.ch/?room==SV%202510
STATUS:CONFIRMED
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