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SUMMARY:Mechanobiology-Inspired Antithrombotic Strategies and Point-Of-Car
 e Microtechnologies
DTSTART:20250505T151500
DTEND:20250505T161500
DTSTAMP:20260501T180312Z
UID:8c38916e51215d858eb68bd0d84dc6f27068576be43e5708e2bc171d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Lining Arnold Ju\, School of Biomedical Engineering\, Un
 iversity of Sydney (AUS)\nBIOENGINEERING SEMINAR\n \nAbstract:\nCardiovas
 cular diseases remain the leading cause of death globally\, with thrombosi
 s playing a central role in their pathogenesis. Current antithrombotic the
 rapies\, while effective\, often carry significant bleeding risks due to t
 heir inability to differentiate between pathological and physiological blo
 od clotting. This presentation introduces our integrated approach that com
 bines fundamental mechanobiology with translational engineering to address
  critical clinical needs in cardiovascular medicine\, potentially transfor
 ming how we diagnose\, monitor\, and treat thrombotic disorders.\n\nFirst\
 , using our single-cell biomechanical nanotools such as Biomembrane Force 
 Probe (BFP)\, we present insights into thrombosis mechanobiology\, particu
 larly focusing on the role of von Willebrand Factor (VWF) and other mechan
 oreceptors (GPIbα\, integrin αIIbβ3 and PIEZO1 ion channels) in disting
 uishing between "good" and "bad" mechanical forces in thrombosis. These he
 lped uncover new therapeutic targets for force-sensitive antithrombotic st
 rategies. Second\, we demonstrate a personalized vessel-on-chip platform t
 hat recreates patient-specific blood vessel geometries and flow conditions
 \, enabling precise evaluation of thrombotic risk and drug responses. Fina
 lly\, we introduce novel point-of-care microtechnologies for rapid blood c
 oagulation testing\, including an AI-powered platform called SmartClot\, w
 hich promises to revolutionize home-based coagulation monitoring. These in
 novations represent a significant advancement toward more effective and sa
 fer antithrombotic treatments\, with potential applications ranging from p
 reventive care to personalized medicine.\n\nBio:\nDr. Ju received his PhD 
 in Biomedical Engineering at Georgia Institute of Technology and Emory Uni
 versity\, USA in 2013. From 2014 to 2019\, he joined the Australian Centre
  for Blood Diseases\, Monash University\, Melbourne\, then Heart Research 
 Institute\, Sydney as an Australian Heart Foundation Postdoc Fellow. In ea
 rly 2020\, Dr. Ju became an independent PI at the University of Sydney (US
 YD)’s new School of Biomedical Engineering and started up the Mechanobio
 logy and Biomechanics Laboratory (MBL).\nDr. Ju works at the biomedical en
 gineering and mechanobiology. His team has pioneered multiple biomechanica
 l nanotools\, including multi-parametric thrombus profiling microfluidics 
 (Nature Materials 2019\; Nature Communications 2024)\, patient-specific ve
 ssel-on-a-chip platform (Advanced Materials 2025\; Science Advances 2025)\
 , single-cell biomembrane force probes (Nature Communications 2018)\, 4D h
 emodynamic modeling (Nature 2021\; Blood 2025) and fluorescent micropipett
 e aspiration assays (Nature Communications 2024). His novel understanding 
 of the mechanics behind blood clot formation has profound implications for
  diagnosing and preventing thrombosis in heart attacks and strokes. His vi
 sion is to build novel platforms that integrate advanced biomanufacturing\
 , high-throughput biomechanical phenotyping\, and generative AI towards ra
 pid and intelligent biosensing technologies for aging\, diabetes\, obesity
 \, hypertension\, vaccine and autoimmune related thrombotic risks.\n\n\nZo
 om link for attending remotely: https://epfl.zoom.us/j/68178203037\n\n\nIn
 structions for 1st-year Ph.D. students planning to attend this talk\, who 
 are under EDBB’s mandatory seminar attendance rule:\nIN CASE you cannot 
 attend in-person in the room\, please make sure to\n\n	send D. Reinhard a 
 note well ahead of time (ideally before seminar day)\, informing that you 
 plan to attend the talk online\, and\, during seminar:\n	be signed in on Z
 oom with a recognizable user name (not any alias making it difficult or im
 possible to identify you).\n\nStudents attending the seminar in-person sho
 uld collect a confirmation signature after the talk - please print your ow
 n signature sheet beforehand (69 kB pdf available for download here). IMPO
 RTANTLY: hang on to this sheet as no signature record is being kept by any
 one else!
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/68178203037
STATUS:CONFIRMED
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