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SUMMARY:BMI Seminar // Lukas Van Oudenhove: Small Molecules\, Big Impact? 
 Short-chain fatty acids as microbiota-gut-brain axis mediators of human ps
 ychophysiology
DTSTART:20251126T121500
DTEND:20251126T131500
DTSTAMP:20260314T215341Z
UID:2a0bd778a91c08b40bed7d7a24d28a3ea47735ff903ce4e3ea520f7d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Lukas Van Oudenhove\, KU Leuven University\, Belgium\nI will f
 irst introduce the concept of humans as holobionts and give an overview of
  the bidirectional microbiota-gut-brain axis pathways through which the gu
 t and its microbiota can impact brain function. I will then zoom in on the
  role of the microbial metabolites short-chain fatty acids as key microbio
 ta-gut-brain axis mediators. After briefly introducing their synthesis and
  local gut effects\, I will focus on two of their key properties that may 
 explain their neuroactive effects. First\, their role as epigenetic modula
 tors will be highlighted and illustrated with our human data on their impa
 ct on stress physiology. Second\, their anti-neuroinflammatory effects wil
 l be presented. The potential relevance of both these effects for major de
 pressive disorder will be discussed. Finally\, new human data on the impac
 t of short-chain fatty acid on GLP-1 and PYY-mediated gut-brain signaling 
 will be shown.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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